妊娠期妇女风疹病毒感染状况分析

Status of of Rubella virus infection among pregnant women

目的通过对妊娠期妇女风疹病毒(RV)Ig M、Ig G抗体水平调查,为预防妊娠期风疹病毒感染和胎儿先天性风疹综合征(CRS)提供参考依据。方法采用酶联免疫吸附试验(ELISA)方法检测孕妇RV-Ig M和RV-Ig G抗体,并按照不同年龄、孕期进行分组和数据分析。结果 359例孕妇风疹Ig M抗体阳性率为1.11%,风疹Ig G抗体阳性率和几何平均浓度(GMC)分别为72.98%和24.52IU/m L;孕妇风疹Ig G抗体水平随着年龄的增长呈现下降趋势,而孕妇对RV易感率随年龄增长有明显增高趋势,≥35年龄组孕妇风疹Ig G抗体阳性率和GMC明显低于35岁以下年龄组;早孕期RV易感率(33.33%)明显高于中孕(24.86%)和晚孕期(26.98%)。结论建议加强风疹及CRS的监测工作,尤其需加强对35岁以上生育的女性人群进行监测和风疹疫苗强化免疫,为做好优生优育,提高人口出生素质提供科学依据。

Objective To investigate the level of Rubella virus（RV）Ig M and Ig G antibodies in pregnant women and toprovide a references for the prevention of RV infection and congenital rubella syndrome（CRS）among pregnan women.Methods ELISA was used to measure the concentrations of RV- Ig M and RV- Ig G antibody in RV infected pregnantwomen and the results in pregnant women of different age and pregnancy group were analyzed. Results The positive rate ofRV- Ig M antibody among pregnant women was 1.11%,the positive rate of RV- Ig G antibody and geometric meanconcentration（GMC）were 72.98% and 24.52 IU/m L; RV- Ig G antibody levels in pregnant women revealed a downtrend asthe growth of the age,RV susceptible rate in pregnant women increased significantly along with increase of age; rubella Ig Gantibody positive rate and GMC inpregnant women over 35 age group significantly were lower than that under 35 years of age;RV susceptible rate of early pregnancy（33.33%）was significantly higher than middle and late pregnancy. Conclusion Surveillance of rubella and CRS should be strengthened,especially the monitoring and intensified immunization of rubellavaccine among the fertile women over age of 35 years to provide scientific basis for carrying out eugenics and improving thequality of the population.