联苯双酯治疗抗痨药物性肝损害的疗效研究

The curative effect study of Bifendate used for anti-tuberculosis drug-induced liver injury

目的探讨联苯双酯在抗痨药物性肝损害治疗中的疗效和应用价值。方法选用济宁市结核病防治所2011年1月至2014年12月门诊治疗的169例初治结核病患者,按单用联苯双酯、单用甘草酸二胺及联苯双酯、甘草酸二胺两药合用(简称"甘联合用")分为三组。所有患者均采用标准化疗方案治疗,并进行统计学分析。结果肝功能异常治疗7d及14d,单用联苯双酯组有效率分别为59.38%、68.75%,单用甘草酸二胺组有效率分别为53.33%、63.33%,甘联合用组有效率分别为93.33%、96.67%;肝功能轻度损害治疗7d及14d,单用联苯双酯组有效率分别为24.00%、60.00%,单用甘草酸二胺组有效率分别为22.73%、54.55%,甘联合用组有效率分别为60.00%、90.00%。单用联苯双酯组与单用甘草酸二胺组治疗肝功能异常和肝功能轻度损害7d及14d治疗有效率差异无统计学意义(P>0.05)。单用联苯双酯组和单用甘草酸二胺组与甘联合用组治疗肝功能异常和肝功能轻度损害7d及14d治疗有效率比效,差异均有统计学意义(P<0.01)。结论治疗肝功能异常及肝功能轻度损害单用联苯双酯与甘草酸二胺疗效相当,甘联合用时效果更好。

Objective To investigate the curative effect and application value of Bifendate which is used for anti-tuberculosis drug- induced liver injury. Methods Totally 169 initial treated tuberculous patients were assembled intuberculosis prevention and treatment institute of Jining from Jan 2011 to Dec 2014. They were divided randomly to 3 groupswith the usage of Bifendate only,Diammonium Glycyrrhizinate only and both. All the patients were given standardchemotherapy,and the results were statistically analyzed. Results Treating abnormal liver function for 7 days and 14 days,the efficiency of group Bifendate were 59.38%,68.75%,group Diammonium Glycyrrhizinate were 53.33%,63.33%,and groupcombination with two medicines were 93.33%,96.67%. Treating mild liver function injury for 7 days and 14 days,theefficiency of group Bifendate were 24.00%,60.00%,group Diammonium Glycyrrhizinate were 22.73%,54.55%,and groupcombination were 60.00%,90.00%. There were no statistically differences in the efficiency of group Bifendate and groupDiammonium Glycyrrhizinate,with treating abnormal liver function and mild liver function injury for 7 days and 14 days（P〈0.01）. Treating mild liver function injury for 7 days and 14 days,the efficiency of group Bifendate were 24.00%,60.00%,groupDiammonium Glycyrrhizinate were 22.73%,54.55%,and group combination were 60.00%,90.00%. There were statisticallydifferences in the efficiency of group combination,compare with group Bifendate and group Diammonium Glycyrrhizinate,withtreating abnormal liver function and mild liver function injury for 7 days and 14 days（P〈0.01）. Conclusion Treatingabnormal liver function and mild liver function injury,the curative effect of Bifendate only or Diammonium Glycyrrhizinate onlyis nearly the same,it becomes better when both the medicines are used.