摘要
目的:观察复方甘草酸单铵S治疗手足口病致肝损害的疗效。方法:选择58例手足口病合并肝损害患儿,以随机数字表法分为治疗组(22例)和对照组(36例)。治疗组患儿静脉滴注复方甘草酸单铵S,对照组患儿静脉滴注还原性谷胱甘肽。对比观察2组患儿治疗前后肝功能指标(丙氨酸转氨酶、天门冬氨酸转氨酶、腺苷脱氨酶、前白蛋白)变化情况。结果:治疗后,治疗组患儿的肝功能指标较治疗前明显好转(P<0.01),且2组患儿肝功能指标的差异无统计学意义(P>0.05)。结论:复方甘草酸单铵S治疗手足口病致肝损害的疗效确切,与还原性谷胱甘肽疗效相当。
OBJECTIVE:To explore the curative efficacy of Compound Ammonium Glycyrrhetate S for injection in treatment of hand-foot-and-mouth disease-induced liver damage.METHODS: 58 children with hand-foot-and-mouth disease-induced liver damage were randomly divided into treatment group (22 cases) and control group (36 cases). The treatment group was treated with Compound Ammonium glycyrrhetate S by intravenous infusion and the control group with reduced glutathione by intravenous infusion.The liver function index including alanine aminotransferase ( ALT) , aspartic acid transaminase, adenosine deaminase ( ADA) and prealbumin in the two groups before and after treatment were recorded.RESULTS: After treatment, the liver function indexes in the treatment group showed significant improvement as compared with before treatment ( P〈0.01 ) yet the differences between the two groups were of no statistical significance ( P 〉0.05 ) .CONCLUSIONS: Compound Ammonium Glycyrrhetate S has confirmed efficacy and it is as effective as reduced glutathione for hand-foot-and-mouth disease-induced liver damage.
出处
《中国医院用药评价与分析》
2015年第6期818-819,共2页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
复方甘草酸单铵S
手足口病
肝损害
Compound ammonium glycyrrhetate S for injection
Hand-foot-and-mouth disease
Liver damage