复方甘草酸单铵S治疗手足口病致肝损害的临床疗效观察

Clinical Efficacy of Compound Ammonium Glycyrrhetate S for Injection in Treatment of Handfoot-and-mouth Disease-induced Liver Damage

目的:观察复方甘草酸单铵S治疗手足口病致肝损害的疗效。方法:选择58例手足口病合并肝损害患儿,以随机数字表法分为治疗组(22例)和对照组(36例)。治疗组患儿静脉滴注复方甘草酸单铵S,对照组患儿静脉滴注还原性谷胱甘肽。对比观察2组患儿治疗前后肝功能指标(丙氨酸转氨酶、天门冬氨酸转氨酶、腺苷脱氨酶、前白蛋白)变化情况。结果:治疗后,治疗组患儿的肝功能指标较治疗前明显好转(P<0.01),且2组患儿肝功能指标的差异无统计学意义(P>0.05)。结论:复方甘草酸单铵S治疗手足口病致肝损害的疗效确切,与还原性谷胱甘肽疗效相当。

OBJECTIVE：To explore the curative efficacy of Compound Ammonium Glycyrrhetate S for injection in treatment of hand-foot-and-mouth disease-induced liver damage.METHODS： 58 children with hand-foot-and-mouth disease-induced liver damage were randomly divided into treatment group （22 cases） and control group （36 cases）. The treatment group was treated with Compound Ammonium glycyrrhetate S by intravenous infusion and the control group with reduced glutathione by intravenous infusion.The liver function index including alanine aminotransferase （ ALT） , aspartic acid transaminase, adenosine deaminase （ ADA） and prealbumin in the two groups before and after treatment were recorded.RESULTS： After treatment, the liver function indexes in the treatment group showed significant improvement as compared with before treatment （ P〈0.01 ） yet the differences between the two groups were of no statistical significance （ P 〉0.05 ） .CONCLUSIONS： Compound Ammonium Glycyrrhetate S has confirmed efficacy and it is as effective as reduced glutathione for hand-foot-and-mouth disease-induced liver damage.