摘要
Rhodium(III)-catalyzed coupling between ketoximes and alkynes via C–H activation and annulation typically followed the[4+2]selectivity to afford isoquinolines.By designing alkynes bearing a highly electron-withdrawing group and under substrate control,we have successfully switched the selectivity of the coupling between oximes and alkynes to the alternative[3+2]annulation,leading to the efficient synthesis of indenamines.This process features good regioselectivity for both substrates,high efficiency,broad substrate scope,and excellent functional group tolerance.
Rhodium（III）-catalyzed coupling between ketoximes and alkynes via C-H activation and annulation typically followed the [4＋2] selectivity to afford isoquinolines. By designing alkynes bearing a highly electron-withdrawing group and under sub- strate control, we have successfully switched the selectivity of the coupling between oximes and alkynes to the alternative [3＋2] annulation, leading to the efficient synthesis of indenamines. This process features good regioselectivity for both sub- strates, high efficiency, broad substrate scope, and excellent functional group tolerance.
基金
supported by the Dalian Institute of Chemical Physics,Chinese Academy of Sciences
the National Natural Science Foundation of China(21472186,21272231)
