以补肾疏肝为调养基方在提升体外受精-胚胎移植成功率的应用研究

Application Research of Using Bushen Shugan Recipe as Basic Recuperation to Enhance the Achievement Ratio of in Vitro Fertilization- Embryo Transplantation

目的:观察以补肾疏肝为基方在提升体外受精-胚胎移植术(IEV-EF)成功率中的应用效果。方法:选取行IEV-EF治疗的不孕症患者60例作为研究对象,采用数字随机表将患者随机均分为观察组和对照组,对照组予以超促排卵治疗,观察组在对照组基础上予以补肾疏肝方加减治疗,行中医症状评分,观察两组促性先腺激素用量(Gn)、促卵泡生成素水平(FSH)、血清抑制素B水平(INH-B)、子宫内膜厚度等的变化情况,记录两组取卵数、受精率、优质胚胎率、妊娠率。结果:观察组Gn用量、FSH分别为(34.10±11.52)支、(7.46±1.68)m IU/ml,明显低于对照组;INH-B为(83.24±11.50)pg/ml,明显高于对照组,差异具有统计学意义(P<0.05)。观察组优质卵率和优质胚胎率分别为(0.84±0.21)%、(0.78±0.07)%,明显高优于对照组;临床妊娠率为66.66%,明显高于对照组的43.33%,差异具有统计学意义(P<0.05);观察组经色暗淡、经量不一、经前烦躁易怒、性欲减退评分分别为(4.85±0.71)分、(5.03±0.46)分、(5.12±0.46)分、(5.17±0.39)分,均显著高于对照组,差异具有统计学意义(P<0.05)。结论:以补肾疏肝为调养基方能够改善临床症状,减少Gn用量,降低促卵泡生成素水平,有利于提高优质胚胎率和临床妊娠率。

Objective： To explore the applicative value of nourishing kidney and dredging liver as basic recuperation to enhance the achievement ratio of in vitro fertilization- embryo transplantation. Methods： Selected 60 patients of infertility with IEV- EF treatment as the research object,with digital random table methods were randomly divided into the observation group and the controlled group,the controlled group was given the treatment of super ovulation,the observation group on the basis of the controlled group was given nourish kidney and dredge liver treatment,TCM symptoms score line,observed the amount of gonadotropic hormone（Gn）,follicle stimulating hormone（FSH） levels,serum levels of inhibin B（INH- B）,endometrial thickness changes of two groups,recorded oocyte,fertilization rate,good quality embryo rate,pregnancy rate of two groups. Results： In the observation group,the dosage of Gn,FSH were（34. 10 ± 11. 52） branch,（7. 46 ± 1. 68） m IU / ml,were significantly lower than the controlled group,INH- B（83. 24 ±11. 50） pg/ml was significantly higher than the controlled group,difference was significant（P 〈0. 05）; high quality egg rate and good quality embryo rates of the observation group were（0. 84 ± 0. 21）%,（0. 78 ± 0. 07）%,were significantly higher than those of the controlled group,the clinical pregnancy rate in the observation group was 66. 66%,was significantly higher than that in the controlled group of 43. 33%,the difference was significant（ P 〈0. 05）; the color bleak,menstrual volume,premenstrual irritability,loss of libido scores in the observation group were（4. 85 ± 0. 71）%,（5. 03 ± 0. 46）,（5. 12 ± 0. 46）,（5. 17 ± 0. 39） were significantly higher than those of the controlled group,the differences were significant（P 〈0. 05）. Conclusion： Nourishing kidney and dredging liver as basic recuperation can improve the clinical symptoms,reduce the dosage of Gn,reduce the FSH levels,is conducive to improve the rate of high quality embryos and clinical pregnancy rate.