摘要
Objective: To compare the clinical characteristics and prognosis between hepatitis virus-related hepatocellular carcinoma(viral HCC) and non-B, non-C HCC(NBC-HCC) among Uyghur patients in Xinjiang province, China. Methods: Between 01/01/2000 and 31/12/2012, 319 Uyghur HCC patients were treated at the Cancer Centre of The First Affiliated Hospital of Xinjiang Medical University. The data for the patients were obtained from a retrospective review of the patients' medical records. A total of 18 patients were excluded from the study because of incomplete information. The patients were classified into two groups: viral HCC and NBC-HCC. The clinical characteristics and prognostic factors were statistically analysed.Results: For all 301 patients, gender(P=0.000), area of residence(P=0.002), diabetes mellitus(P=0.009), BMI(P=0.000), cirrhosis(P=0.000), tumour stage(P=0.004), Child-Pugh class(P=0.000), the TBIL level(P=0.000), and the alpha-fetoprotein(AFP) level(P=0.000) were significantly different between the NBC-HCC and viral HCC groups. The NBC-HCC patients tended to be diagnosed at advanced stages; however, the NBC-HCC patients exhibited lower Child-Pugh scores than the viral HCC patients. In all patients examined, the 0.5-, 1-, 3- and 5-year overall survival(OS) rates were 35.6%, 20.3%, 12.6% and 4.5%, respectively. No significant difference in OS was observed between the two groups(P=0.124). Cox multivariate analysis revealed that age(RR =1.539, P=0.001), TNM stage(RR =12.708, P=0.000), portal vein tumour thrombus(PVTT)(RR =2.003, P=0.000), Child-Pugh class(RR =1.715, P=0.000), and TACE + radiotherapy/RFA(RR =0.567, P=0.000) were significant independent prognostic factors for HCC patients. Conclusions: The clinical characteristics differ between Uyghur patients with NBC-HCC and viral HCC. HCC in the Xinjiang region displays specific regional characteristics. Age, TNM stage, PVTT, Child-Pugh class and TACE + radiotherapy/RFA are significant risk factors that influence patient survival.
Objective: To compare the clinical characteristics and prognosis between hepatitis virus-related hepatocellular carcinoma(viral HCC) and non-B, non-C HCC(NBC-HCC) among Uyghur patients in Xinjiang province, China. Methods: Between 01/01/2000 and 31/12/2012, 319 Uyghur HCC patients were treated at the Cancer Centre of The First Affiliated Hospital of Xinjiang Medical University. The data for the patients were obtained from a retrospective review of the patients' medical records. A total of 18 patients were excluded from the study because of incomplete information. The patients were classified into two groups: viral HCC and NBC-HCC. The clinical characteristics and prognostic factors were statistically analysed.Results: For all 301 patients, gender(P=0.000), area of residence(P=0.002), diabetes mellitus(P=0.009), BMI(P=0.000), cirrhosis(P=0.000), tumour stage(P=0.004), Child-Pugh class(P=0.000), the TBIL level(P=0.000), and the alpha-fetoprotein(AFP) level(P=0.000) were significantly different between the NBC-HCC and viral HCC groups. The NBC-HCC patients tended to be diagnosed at advanced stages; however, the NBC-HCC patients exhibited lower Child-Pugh scores than the viral HCC patients. In all patients examined, the 0.5-, 1-, 3- and 5-year overall survival(OS) rates were 35.6%, 20.3%, 12.6% and 4.5%, respectively. No significant difference in OS was observed between the two groups(P=0.124). Cox multivariate analysis revealed that age(RR =1.539, P=0.001), TNM stage(RR =12.708, P=0.000), portal vein tumour thrombus(PVTT)(RR =2.003, P=0.000), Child-Pugh class(RR =1.715, P=0.000), and TACE + radiotherapy/RFA(RR =0.567, P=0.000) were significant independent prognostic factors for HCC patients. Conclusions: The clinical characteristics differ between Uyghur patients with NBC-HCC and viral HCC. HCC in the Xinjiang region displays specific regional characteristics. Age, TNM stage, PVTT, Child-Pugh class and TACE + radiotherapy/RFA are significant risk factors that influence patient survival.
基金
supported by a grant from the Urumqi Science and Technology Project Foundation of China(No.H111313001)