成纤维细胞生长因子9(FGF9)的研究进展

Research Progresses On The Fibroblast Growth Factor 9

成纤维细胞生长因子9(fibroblast growth factor 9,FGF9)是成纤维细胞生长因子家族(FGFs)的成员之一。广泛分布于人体各种组织中,它参与骨骼发育、血管形成、胚胎发育、损伤修复、细胞凋亡、神经再生、肿瘤生长等多种生理和病理的过程,可有效促进有丝分裂和细胞生长。研究发现,FGF9不仅在骨骼发育和生长期对软骨形成和成骨生成起着重要的作用,而且对卵巢癌的发生、神经再生、性腺分化等方面也有重要的影响,对FGF9作为一个有用治疗靶点发挥作用的功能和机制仍有待进一步的发现及研究。现针对FGF9的特点,综述了其在表达及适应征机制方面的研究进展,为FGF9进一步的研究及合理开发利用提供参考。

FGF9 （fibroblast growth factor 9, FGF9 ） is one of the fibroblast growth factor （FGF） family members. It is widely distributed in various tissues of human body and involved in bone development, angiogenesis, embryonic development, damage repair, cell apoptosis, nerve regeneration, tumor growth and other physiological and pathological processes, and can effectively promote mitosis and cell growth. Current evidence suggests that FGF9 may play a prominent role not only in bone development and growth of cartilage into bone formation and generation, but also has a significant impact on aspects of ovarian cancer, nerve regeneation, gonadal differentiation, there remains much to be discovered and investigated on the functions and mechanisms of FGF18. The research progress in the mechanism of the expression of FGF9 was reviewed and its indication aspects, providing the reference for the further study of FGF9 and its rational development and utilization.