慢性肾脏病伴代谢综合征患者大动脉僵硬度水平及相关因素分析

Analysis of arterial stiffness and associated factor in chronic kidney disease patients with metabolic syndrome

目的观察慢性肾脏病伴代谢综合征患者大动脉僵硬度水平及相关因素，分析其相关性。方法选择伴有代谢综合征的慢性肾脏病患者共247例，观察及记录其年龄、体重、血压、血糖、血脂等指标；测定患者颈一股脉搏波速度（CV—PWV），加以分级并进行分析。结果多元逐步回归分析显示，年龄、SBP、PP和HDL—C是影响患者CF—PwV的独立因素，所建立回归方程为CF—PWV（m／s）=2．981＋0．025年龄（岁）＋0．032SBP（mmHg）＋0．044PP（mmHg）＋0．230HDL—C（mmol／L），各偏回归系数P〈0．05。结论伴代谢综合征的慢性肾脏病患者存在血管硬化的比例明显，CF—Pwv与患者年龄、SBP、PP、HDL—C等具有相关性，提示相关客观指标可作为血管硬化程度评价依据。通过一定程度干预血压、血脂等相关因素可能对预防或延缓慢性肾脏病伴代谢综合征患者血管硬化起作用。

Objective To observe arterial stiffness, its related risk factors and analyze its con＇elation in chronic kidney disease patients with metabolic syndrome. Methods 247 CKD patients with MS were recruited, their age, weight, blood pressure, blood glucose amd blood lipid were observed and record. In addition, the carotid femoral pulse wave velocity（CF-PWV） was graded and analyzed. Results Multivariate regression analysis revealed that CF-PWV was positively and independently associated with age, SBP, PP, and HDL-C, the regres- sion equation was CF-PWV （m/s）=2.981＋0.025age （years old）＋0.032SBP （mm Hg）＋0.044PP （ram Hg）＋ 0.230HDL-C （mmol/L）, the partial regression coefficient of P〈0.05. Conclusion The proportion of arterial stiff- ness in CKD patients with MS increased markedly. CF-PWV related to the patients age, SBP, PP HDL-C and other factors. It provides a important basis for that the relevant objective index can be used as arterial stiffness de- gree. Through a certain degree of associated factor of blood pressure, blood lipid intervention may play a role in preventing or delaying arterial stiffness in CKD patients with MS.