高尿酸血症与脑血管疾病关系的探讨

Discuss the relationship between hyperuricemia and cranial vascular disease

目的探讨高尿酸血症和脑血管疾病的关系。方法选择2011年8月至2012年6月我院住院的脑血管疾病患者143例,其中脑梗死患者85例(脑梗死组),脑出血患者58例(脑出血组),选择同期体检健康者156例作为对照组。采用日立HITACHI-7600全自动生化分析仪检测血清尿酸水平,并对结果进行统计分析。结果三组间血尿酸水平差异有统计学意义(F=16.21,P<0.05)。脑梗死组和脑出血组患者血尿酸水平均显著高于对照组,差异均有统计学意义(P均<0.05)。三组间高尿酸血症的发病率差异有统计学意义(χ2=4.572,P<0.05),其中脑梗死组患者高尿酸血症的发病率最高,为41.18%。结论血清尿酸水平异常升高可提示脑血管疾病的发生,但不能辅助鉴别疾病类型。高尿酸血症可导致脑血管疾病的发生,对于脑血管疾病患者应同时注意对高尿酸血症的诊断治疗。

Objective To discuss the relationship between hyperuricemia and cranial vascular disease. Methods 143 cases hyperuricemia patients, which including 85 cases cerebral infarction patients（cerebral infarction group） and 58 cases cerebral hemorrhage patients（cerebral hemorrhage group） were selected in our hospital from August 2011 to June 2012. 156 cases healthy people（control group） were selected in the same time. Level of serum uric acid was detected by HITACHI-7600 automatic biochemical analyzer. All data were analyzed statistically. Results There was statistical significance in the difference of serum uric acid levels among three groups（F= 16.21, P 0.05）. Levels of serum uric acid in cerebral infarction group and cerebral hemorrhage group were all higher than that of control group, and the differences all had statistical significance（Pall〈0.05）. There was statistical significance in the difference of positive rate of hyperuricemia among three groups（χ2= 4.572, P 0.05）. The highest morbidity of hyperuricemia was cerebral infarction patients（41.18%）. Conclusion Abnormally elevated serum uric acid may indicate the occurrence of cranial vascular disease, but can not identify the disease type. Hyperuricemia can lead to the occurrence of cranial vascular disease. For patients with cranial vascular disease should also pay attention to diagnosis and treatment of hyperuricemia disease.