头孢呋辛钠在Beagle犬体内的毒代动力学研究

Toxicokinetics of Cefuroxime sodium in Beagle dogs

目的探讨头孢呋辛钠在Beagle犬体内的毒代动力学,为临床用药提供参考。方法选取Beagle犬7只,随机分为阴性对照组和注射用头孢呋辛钠(1.65 g/kg)组,以静脉滴注方式给药。血浆样品采用反相高效液相色谱法测定头孢呋辛浓度,用DAS计算毒代动力学参数。结果头孢呋辛钠在Beagle犬体内的毒代动力学主要参数为:血浆药时曲线下面积(AUC0-t)为(4 745±1 607)mg(L·h),峰浓度(Cmax)为(2520±407)mg/L,平均滞留时间(MRT0-t)为(1.8±0.3)h,清除率(CL)为(0.38±0.16)L(h/kg),分布容积(Vd)为(0.56±0.15)L/kg。结论头孢呋辛在Beagle犬体内消除较快,基本分布于血浆,提示应无明显毒性蓄积。

Objective In order to study the toxicokinetics of cefuroxime sodium in Beagle dogs,and provide scientific basis for clinical use.Methods The concentrations of plasma cefuroxime in Beagle dogs after single intravenous infusion in dose of 1.65 g/kg were determined by HPLC-UV.The toxicokinetic parameters were computed by using DAS program.Results The main toxicokinetic parameters were as follows：AUC0-t=（4745±1607）mg/（L·h）,Cmax=（2520±407）mg/L,MRT0-t=（1.8±0.3）h,CL=（0.38±0.16）L/（h·kg）,Vd=（0.56±0.15）L/kg.Conclusion Cefuroxime is rapidly eliminated and distributed mainly in plasma.The result shows no obviously accumulation toxicity.