2004年～2013年肺癌患病风险基因相关临床研究文献的计量学分析

Bibliometrics analysis of clinical research literature on lung cancer predisposing genes from 2004 to 2013

目的掌握近10年来国内外肺癌患病风险基因相关临床研究动态。方法以Embase、Pubmed为文献检索数据库(2004年1月至2013年12月),分别对纳入文献的出版年、国家、期刊、研究机构、作者及所研究基因进行计量学分析。结果该领域年发文量一直较多,2004年到2008年缓慢增长,2008年后则趋向平缓;发文量最多的国家、期刊、机构及作者分别为美国、《Lung Cancer》(肺癌)、MD Anderson Cancer Center(美国MD安德森癌症中心)、Park JY;该领域共统计出相关基因312个,其中以p53和CDKN1A基因研究最多。结论肺癌患病风险基因相关临床研究仍受广大研究员关注,且涉及基因种类繁多,寻找有特异性和敏感性的基因至关重要。

Objective To investigate the status of clinical research literatures on lung cancer predisposing genes in recent 10 years. Methods The clinical trails related to lung cancer predisposing genes were searched through Embase, and Pubmed database between January 2004 and December 2013. The publication years, origin of countries, journals, institutions, authors and genes of the eligible bibliometric were analyzed. Results A total of 674 publications were included. The numbers of publications was always high,increased slowly in the first five years, and were stable in the second five years. The origin of countries,journals, institutions and authors with the largest number of publications was United States, Lung Cancer, MD Anderson Cancer Center, Park, J.Y, respectively. The publications included 312 genes in this field, with p53 and CDKN1 A gene being the most. Conclusion Lung cancer predisposing genes are still under the researchers＇ attention, and involved a wide variety of genes. Searching for more sensitive and specific genes will be an important target in the future researches.