抗癌保肝汤联合化疗对原发性肝癌的临床疗效观察

ClinicalO bservation onK ang'ai Baogan Decoction Combined with Chemotherapy for Primary Liver Cancer

目的:观察抗癌保肝汤联合化疗对原发性肝癌的临床疗效。方法:将原发性肝癌患者共80例,随机分为治疗组与对照组两组,每组各40例。所有患者均按西医化疗后常规处理原则进行相应的治疗措施。对照组:采用FP方案进行化疗,即5—FU+顺铂,经动脉泵小剂量持续灌注。连续5 d,每4周重复1次,为1疗程。至少完成2个化疗周期。治疗组:在化疗基础上,口服中药抗癌保肝汤。两组疗程均为2个月。疗效结束后观察疗效。结果:治疗结束后统计显示,在两组客观有效率比较中,治疗组为37.5%,对照组为25.0%,两组相比,有统计学差异(P<0.05)。在两组治疗前后Karnofsky评分比较中,治疗组好转率为55.0%,对照组好转率为30.0%,两组相比,有统计学差异(P<0.05)。在两组治疗前后体质量增长情况比较中,治疗组好转率为45.0%,对照组好转率为27.50%,两组相比,有统计学差异(P<0.05)。在两组治疗前后白细胞计数、谷丙转氨酶及甲胎蛋白水平比较中,治疗组在治疗后均明显优于对照组治疗后,两组相比,差异显著(P<0.05)。两组治疗后化疗不良反应比较,治疗组在骨髓抑制、呕吐、腹泻、乏力、脱发等方面均低于对照组,有统计学差异(P<0.05)。结论:采用中药抗癌保肝汤联合化疗治疗原发性肝癌,可以提高患者的临床缓解率,能明显提高患者的Karnofsky评分及体质量,有效地改善患者的生活质量,此外还可以提高患者白细胞,改善谷丙转氨酶及甲胎蛋白水平,在很大程度上减少了化疗药物的毒副反应,提高了临床疗效,其效果明显优于对照组,值得临床推广使用。

Objective ： To observe the clinical curative effect of KangM Baogan Decoction combined with chemotherapy for primary liver cancer. Methods ： 80 cases of primary liver cancer were randomly divided into treatment group and control group ,40 cases in each group. All the patients were given corresponding treatment measures according to the conventional western medicine treatment principle after chemotherapy. Control group：treated with FP regimen,namely 5 FU ＋ cispla- tin,through continuous arterial perfusion pump with small dose for 5 consecutive days, repeated every 4 weeks for 1 course, completed at least 2 cycles of chemotherapy. Treatment group：based onchemotherapy,took Kang^ti Baogan Decoc- tionorally. Two groups were treated for 2 months. Observe the curative effect after treatment. Results ： After the treatment, the objective efficient was 37.5% in the treatment group and that in the control group was 25% and there was statistical difference between two groups （ P 〈 O. 05 ）. In comparison of Karnofsky score before and after treatment in the two groups,the treatment group＇s improvement rate was 55% and control group＇swas 30% and there were significant differ- ences （P 〈 O. 05 ）. In the comparison of the two groups lncrease of body weight, the improvement rate was 45% in the treatment group and the control group~ was 27.50% and there were significant differences （P 〈0.05）. In comparison of the white blood cell count of the two groups before and after treatment, atanine aminotransferase and alpha fetoprotein lev- els in treatment group after treatment were significantly better than those of the control group after treatment with signifi- cant difference （P 〈 O. 05 ）. Comparison of the toxicity of chemotherapy in the two groups after the treatment, bone mar- row suppression, vomiting, diarrhea, fatigue and alopecia in the treatment group were lower than those in the control group and there were significant differences （ P 〈 O. 05 ）. Conclusion： The use of Chinese medicine Kang＇ai BaoganDecoction combined with chemotherapy in the treatment of primary hepatic carcinomacan improve the remission rate of patients and significantly improve the Karnofsky score and body weight of patientsand effectively improve the quality of life of patients. It also can improve the patients＇white blood cells and improve glutamate pyrnvate transaminase and alpha fetoprotein levels,largely reduce the side effects of chemotherapy and improve the clinical curative effect. And the effect is obviously better than the control group＇s. It is worthy of clinical use.