中西医结合治疗新生儿高胆红素血症疗效观察

Efficacy and Safety Evaluation of Integrative Treatment of Neonatal Hyperbilirubinemia

目的:探讨中西医结合治疗新生儿高胆红素血症患儿疗效观察及安全性评价,为临床治疗提供一定参考依据。方法:将86例患儿按照随机数字表法随机分为两组,分别为对照组和观察组各43例。对照组采用熊去氧胆酸治疗,观察组采用茵栀黄颗粒联合熊去氧胆酸治疗。两组患儿均采取常规对症治疗。两组疗程均为5d。对比分析两组治疗前后胆红素水平变化、治疗后黄疸消退时间和胆红素开始下降时间、治疗后疗效及治疗间不良反应发生情况。结果:两组患者胆红素水平治疗后较治疗前显著下降,且差异具有统计学意义(P<0.05);观察组患儿胆红素水平治疗后显著低于对照组,且具有统计学差异(P<0.05);观察组黄疸消退时间和胆红素开始下降时间明显短于对照组,且差异具有统计学意义(P<0.05);观察组总有效率(95.35%)显著高于对照组(81.40%)(P<0.05);两组治疗期间均未发生明显不良反应。结论:茵栀黄颗粒联合熊去氧胆酸治疗新生儿高胆红素血症患儿疗效显著,可明显降低血清胆红素,缩短黄疸消退时间和胆红素开始下降时间,且无明显不良反应,安全可靠,具有重要临床研究价值,值得进一步推广应用。

Objective：To investigate the efficacy and safety evaluation of the combination therapy in children with neo- natal hyperbilirubinemia and to provide a reference for clinical treatment Methods： 86 patients were randomly divided into two groups respectively, the control group （ n = 43 ） and the observation group （ n = 43 ）. The control group was treated with ursodeoxycholic acid treatment and observation group used inzhihuang particles combined ursodeoxycholic acid treatment. Two groups children took the conventional symptomatic treatment. The treatment lasted 5 d. The bilirubin levels ,jaundice relieving time, adverse events and efficacy were compared after treatment. Results ： After treatment, the two groups＇bilirubin level was significantly lower than that before treatment with significant difference （P 〈0.05 ） and bilirubin levels in treatment group was significantly lower than that of the control group （ P 〈 0.05 ）. The observation group jaundice and bilirubin relieving time was significantly shorter than that of the control group （ P 〈 0.05 ）. The total effi- ciency of the observation group （95.35%） was significantly higher than that of the control group（81.40% ） and there was a statistically significant difference （ P 〈 0.05 ）. There was no obvious adverse reaction during treatment. Conclusion ： Yinzhihuang particles combined with ursodeoxycholic acid treatment of neonatal hyperbilirubinemia can significantly reduce serum bilirubin, shorten jaundice time and relieving time of bilirubin, and has no significant adverse reactions. It is safe and reliable and has important clinical research value,worthy of further application.