西宁地区脑小血管病危险因素的Logistic回归分析研究

The Logistic Regression Analysis of Brain Small Vascular Disease Risk Factors in Xining Area

目的:探讨西宁地区脑小血管病危险因素。方法:以2012年12月—2013年7月我科住院的脑小血管患者75例为患病组,同期在我科因某种疾病住院非脑小血管病患者62例作为对照组。按照病例-对照研究设计对所有研究对象进行危险因素调查,使用SPSS16.0建立数据库并进行统计分析。结果:1单因素分析显示:颈动脉硬化、总胆固醇、低密度脂蛋白、血红蛋白、肾小球滤过率对脑小血管病发病有影响;2非条件多因素Logistic回归分析显示:高总胆固醇血症、高低密度脂蛋白血症是脑小血管病的独立危险因素。结论:增龄、高总胆固醇血症、高低密度脂蛋白血症可以明显增加西宁地区脑小血管病的患病风险,应加强对西宁地区高龄人群的脑小血管病的筛查以及对血脂异常人群的管理,以减少西宁地区脑小血管疾病的发病并降低认知功能损害及痴呆的发生。

Objective：To investigate the risk factors of brain small vascular disease in Xining area. Method：75cases of patients with brain small vascular disease and 38 cases with no brain small vascular disease were enrolled between December 2012 to July 2013 in our department and the former as the trial group and the later as the control group during the corresponding period. The risk factors of the two groups were inquired according to case- control study design. A database was used and statistical analysis undergone by SPSS16. 0. Results：The unconditional multiple- factor Logistic regression analysis indicated that age,high total cholesterol and high low density lipoprotein are the independent risk factors of the brain small vascular disease onset. Conclusions：Aging,high total cholesterol and high low density lipoprotein can significantly increase the risk of the brain small vascular disease; The screening of older population and the management of dyslipedemia should be strengthened,then the morbidity of brain small vascular disease and the incident of cognitive dysfunction and dementia can be reduced in Xining area.