金双歧预防国内婴幼儿抗生素相关性腹泻的Meta分析

Prevention of antibiotic associated diarrhea by Live Combined Bifidobacterium and Lactobacillus Tablets in infants in China: A Meta analysis

目的系统评价金双歧对国内婴幼儿抗生素相关性腹泻(ADD)的预防作用及安全性。方法计算机联机检索Cochrane图书馆、Em Base、Pub Med、CNKI、CBM、Medline、VIP、万方数据库(各数据库检索时间为创建至2014年10月)中关于金双歧预防ADD的随机对照试验(RCT),用Rev Man 5.3软件对数据进行Meta分析。结果共纳入14篇RCT,包括1 638例患儿。Meta分析结果显示,金双歧预防婴幼儿ADD效果优于对照组[RR=0.41,95%CI(0.35,0.47),P<0.00001]。结论基于现有临床证据,金双歧预防ADD有效,安全性高。但由于纳入研究数量较少,研究质量不统一,本结论尚需要更多大样本、高质量临床RCT予以证实。

Objective To systematically evaluate the preventive effect and safety of Live Combined Bifidobacterium and Lactobacillus Tablets for antibiotic associated diarrhea（ AAD） in infants in China. Methods The randomized controlled trials（ RCTs） of S. Boulardii for AAD in infants were retrieved by computer in the Cochrane Library,EMbase,Pub Med,CNKI,CBM,VIP and WANFANG DATA（ from their creation dates to November,2014）.Meta analysis was carried out on the results by Rev Man 5. 3 software. Results Fourteen RCTs were retrieved,which included 1638 patients. The Meta analyses showed that the effects of Live Combined Bifidobacterium and Lactobacillus Tablets in the prevention of ADD in infants were superior to those of the control group [RR = 0. 41,95% CI（ 0. 35,0. 47）,P〈0. 00001]. Conclusion Based on the present clinical evidences,Live Combined Bifidobacterium and Lactobacillus Tablets are effective and safe for prevention of ADD. However,due to the small amount of included studies,this conclusion needs to be identified by more and larger samples and high-quality RCTs.