伴高尿酸血症的老年及老年前期IgA肾病临床病理分析

Clinical Pathological Analysis of Senile and Pre-senile IgA Nephropathy with Hyper-uricemia

目的:探讨伴高尿酸血症的老年及老年前期Ig A肾病患者的临床及病理特点。方法:通过回顾性分析2009年1月1日-2014年12月31日48例老年及老年前期Ig A肾病患者,分成伴高尿酸血症Ig A肾病患者与不伴高尿酸血症Ig A肾病患者,比较两组临床与病理差异。结果:高尿酸血症组与尿酸正常组比较,血肌酐、24 h尿蛋白定量、血总胆固醇升高,差异均有统计学意义(P<0.05)。高尿酸血症组肾脏病理改变以Lee氏Ⅲ、Ⅳ级多见,而正常尿酸组组则以Lee氏Ⅱ、Ⅲ级为主。结论:伴有高尿酸血症的老年及老年前期Ig A肾病患者临床和病理损伤均重于尿酸正常的老年及老年前期Ig A肾病患者,应重视老年及老年前期Ig A肾病患者的血尿酸控制。

Objective To observe the clinical pathological features of senile and pre-senile IgA nephropathy with hyper-uricemia.Methods A retrospective study was enrolled for 48 senile and pre-senile IgA nephropathy patients. And the 48 patients were divided into two groups： 27 patients with hyper-uricemia and 21 patients with uric acid normal level. Results Serum creatinine,24 hours urine protein, cholesterol were increased in senile and pre-senile IgA nephropathy with hyper-uricemia. Lee＇s Ⅲ, Ⅳ grade were more common in senile and pre-senile IgA nephropathy with hyper-uricemia. Conclusion The clinical pathological damage in senile and pre-senile IgA nephropathy with hyper-uricemia is more severe than in the senile and pre-senile IgA nephropathy with uric acid normal level.