血清胱抑素C在糖尿病肾病早期诊断中的应用价值分析

目的探讨血清胱抑素C在糖尿病肾病早期诊断中的临床应用价值。方法选取2型糖尿病患者166例,按照尿清蛋白排泄率(UAER)将166例患者分为3组:正常尿蛋白组(n=68)、微量尿蛋白组(n=51)和大量尿蛋白组(n=47),并选取健康体检者65例作为对照组,比较4组人群的胱抑素C(Cys-C)、尿素氮(BUN)、血肌酐(Scr)和肌酐清除率(CCr)。结果 Cys-C结果方面,正常尿蛋白组为(1.12±0.22)mg/L、微量尿蛋白组为(1.71±0.43)mg/L,大量尿蛋白组为(2.86±1.26)mg/L,均显著高于对照组的(0.74±0.33)mg/L,差异均有统计学意义(P<0.05);微量尿蛋白组及大量尿蛋白组的BUN、Scr、CCr分别与对照组相比,差异具有统计学意义(P<0.05),而正常尿蛋白组与对照组之间差异无统计学意义。结论 Cys-C灵敏度高于BUN、Scr、CCr,对糖尿病肾病的早期诊断具有重要价值。

Objective To study the application value of serum cystatin C in early diagnosis of diabetic nephropathy. Methods 166 patients with type 2 diabetes mellitus were selected and divided into normal urine protein groupn （n=68）, trace urine protein group （n=51） and massive urine protein group （n=47） according to urinary albumin excretion rate. 65 health people were selected as control group. The levels of serum cystatin C （Cys-C）, blood urea nitrogen （BUN）, sentm creatinine （Scr） and creatinine clearance rate （CCr） in four groups were compared. Results Cys-C outcome, normal urine protein group （1.12±0.22） mg / L, microalbuminuria group （1.71±0.43） mg/L, a large number of urine protein group （2.86±1.26） mg/L, were significantly higher than the control （0.74±0.33） mg/L, the difference was statistically significant （P 〈0.05）; microalbuminuria group and a large group of urinary protein BUN, Scr, CCr respectively compared with the control group, the difference statistically significant （P 〈0.05）, but no urinary protein between normal group and control group was statistically significant. Conclusion Sensitivity of Cys-C was higher than BUN, Scr, CCr. Cys-C had an important application value in the early diagnosis of diabetic nephropathy.