三种血清指标联合检测在类风湿关节炎中的诊断意义

目的评价抗环瓜氨酸肽抗体(抗CCP)、抗葡萄糖-6-磷酸异构酶抗体(抗GPI)以及类风湿因子(RF)三种血清指标在诊断类风湿关节炎中的意义。方法用随机抽样的方法选取患有类风湿性关节炎的患者160例为观察组,非类风湿性关节炎患者146例为对照组,使用相应的检测方法对抗环瓜氨酸肽抗体(抗CCP)、抗葡萄糖-6-磷酸异构酶抗体(抗GPI)以及类风湿因子(RF)进行测定,观察各指标对类风湿性关节炎(RA)的诊断价值。结果对类风湿性关节炎灵敏度由高到低依次为:RF(88.75%),抗CCP(71.25%),抗GPI(50%),特异性由高到低依次为:抗CCP(97.26%),抗GPI(93.56%),RF(83.56%)。联合检测以抗CCP、抗GPI、RF联合检测的敏感性和特异性之和最大。结论抗CCP、抗GPI在类风湿关节炎诊断中有良好的灵敏度和特异性,联合RF检测能极大地提高类风湿关节炎诊断的准确性。

Objective To evaluate the effect of cyclic citrulline antibody resistance （ACCP）, resistance to glucose-6-phosphate isomerase antibody （AGPI） and rheumatoid factor （RF） three serum indexes in the comprehensive testing of rheumatoid arthritis （RA） in order to diagnose. Methods 160 patients with rheumatoid arthritis were selected as observation group and 146 cases with rheumatoid arthritis as control group by random sampling method, and then detected antibodies against ring citrulline, glucose-6-phosphate isomerase antibody and rheumatoid factor. The effects of three kinds of serum material and the value of diagnosis to rheumatoid arthritis were observed. Results The positive cases of three serum index results were higher in observation group compared with control group. The order of sensitivity of rheumatoid arthritis from high to low was RF （88.75%）,ACCP （71.25%）, AGPI （50%）. The order of specificity of rheumatoid arthritis from high to low was ACCP （97.26%）, AGPI （93.56%）,RF （83.56%） Conclusion The combination of Ring citrulline antibody resistance, resistance to glucose-6-phosphate isomerase antibody and rheumatoid factor had a high specificity and sensitivity in the diagnosis of rheumatoid arthritis.