线粒体tRNA突变与高血压关系的研究进展

Relationshipof mitochondrial tRNA mutationwith development of hypertension：aresearchprogress

线粒体基因突变与多种疾病的发生有关，虽然转移RNA（tRNA）基因只占整个线粒体基因组的10%，但它们却是研究线粒体基因突变与疾病发生关系的热点。既往高血压遗传学的研究主要集中在核基因方面，近年来研究发现线粒体DNA突变可能参与原发性高血压（EH）的发生与发展，且越来越多的线粒体tRNA也被报道与EH的发生和发展密切相关。本文对线粒体tRNA突变与高血压发病的关系及其机制进行了综述。

Mitochondrial DNA mutation is associated with a variety of diseases. Althoughonly constituting 10% of the entire mitochondrial genome,the transfer RNA（tRNA） geneshave become a hotspotin the study concerning the relationship of the mitochondrial gene mutation with diseases. Previous studies on the genetics of hypertension mainlyconcentrated in the nuclear genes, butrecent studies found that mitochondrial DNA mutations may be involved in the occurrence and development of essential hypertension （EH）.What’s more, much evidence indicated that close association was found between mitochondrial tRNA with theEH occurrence and development.In this article, we summarized the relationship between themitochondrial tRNA mutation and pathogenesis of hypertension, andreviewed the underlyingmechanism.