惠州地区人乳头瘤病毒(HPV)的亚型分布特点及其与年龄的相关性分析

Correlation of Human Papilloma Virus(HPV) Subtypes Distribution Characteristics and Age in Huizhou Region

目的：探讨惠州地区人乳头瘤病毒（HPV）的亚型分布特点及其与年龄的相关性。方法：收集2576例2013年1月-2014年12月本院门诊和体检的妇女宫颈分泌物中的脱落细胞,依据年龄分为低龄组（20～29岁）、中低龄组（30～39岁）、中龄组（40～49岁）、高龄组（〉49岁）,采用HPV导流杂交快速基因分型技术检测HPV亚型,统计分析所有受试者HPV的亚型分布特点及其与年龄的关系。结果：惠州地区2576例标本经HPV基因检查和分型诊断筛查出412例HPV感染阳性,感染总阳性率为15.99%,其中HPV亚型52感染率最高（2.45%）,HPV亚型2感染率最低（0.08%）,前者明显高于后者,差异有统计学意义（字2=7.72,P〈0.01）;高危型HPV感染率为14.01%,低危型HPV感染率为1.98%,前者明显高于后者,差异有统计学意义（字2=7.13,P〈0.01）;低龄组HPV感染所占百分比为29.38%,中低龄组HPV感染所占百分比为57.77%,中龄组HPV感染所占百分比为9.45%,高龄组HPV感染所占百分比为3.40%,中低龄组〉低龄组〉中龄组〉高龄组,差异有统计学意义（P〈0.05）。结论：惠州地区HPV感染几率具有显著的亚型和年龄分布异质性,对指导HPV疫苗研究以及HPV感染早期预防和治疗具有重要的临床价值。

Objective：To discuss correlation of human papilloma virus（HPV） subtypes distribution characteristics and age in Huizhou region.Method：2576 women of cervical secretions exfoliated cells were selected from January 2013 to December 2014 in our hospital outpatient service and examination, on the basis of age, all women was divided into young group（20-29 years old）,mid-young group（30-39 years old）, middle age group（40-49 years old）, old age group（49 years old）, HPV diversion hybridization rapid genotyping technology was used to detect HPV subtype, analysed all the subjects of HPV subtypes distribution characteristics and its relationship with age.Result： In Huizhou region,2576 cases of specimens after HPV gene examination and classification diagnostic screening out of 412 cases were positive for HPV infection, total infection positive rate was 15.99%,and HPV subtypes 52 infection rate was the highest（2.45%）,HPV subtype 2 infection rate was the lowest（0.08%）, the former was significantly higher than the latter,the difference was statistically significant（字2=7.72,P〈0.01）.High-risk type HPV infection rate was 14.01%,low-risk HPV infection rate was 1.98%,the former was significantly higher than the latter（字2=7.13,P〈0.01）.Young group of HPV infection percentage was 29.38%, mid-young group of HPV infection percentage was 57.77%, middle age group of HPV infection percentage was 9.45%, old age group of HPV infection percentage was 3.40%, mid-young groupyoung groupmiddle age groupold age group（P〈0.05）.Conclusion：Risk HPV infection in Huizhou has significant heterogeneity subtypes and age distribution, to guide the HPV vaccine research and early prevention and treatment of HPV infection has important clinical value.