脂肪肝患者血清瘦素水平研究

The Study of Serum Leptin Level in Patients with Fatty Liver

目的:研究脂肪肝患者的血清瘦素水平,分析血清瘦素和脂肪肝发病的关系。方法:随机选取2013年6月-2015年5月到本院进行治疗的脂肪肝患者246例为观察组,再选择同期到体检中心进行检查的140例正常人进行对照研究为对照组。对两组的空腹血清瘦素含量等做出检测和分析,在此基础上加以比较研究。结果:观察组患者中,轻度酒精性脂肪肝和非酒精性脂肪肝患者的血清瘦素分别为(4.58±0.91)ng/m L和(4.11±1.83)ng/m L;中度酒精性脂肪肝和非酒精性脂肪肝患者的血清瘦素分别为(6.25±1.78)ng/m L和(6.58±2.01)ng/m L;重度酒精性脂肪肝和非经酒精性脂肪肝患者的血清瘦素分别为(10.34±2.51)ng/m L和(8.57±1.23)ng/m L;对照组的血清瘦素为(3.74±1.93)ng/m L。轻、中、重度酒精性脂肪肝和非酒精性脂肪肝患者的血清瘦素明显高于正常人,两组比较差异有统计学意义(P<0.05)。结论:轻、中、重度酒精性脂肪肝和非酒精性脂肪肝患者的血清瘦素均高于正常人的血清瘦素,而且血清瘦素对于患者脂肪肝的轻重程度也具有直接的影响,需要在临床上加以治疗干预。

Objective：To research the fatty liver patients blood thin element level, analysis the relationship between blood thin element and fatty liver disease. Method： 246 fatty liver patients from June 2013 to May 2015 were selected as the research object which was the observation group,140 normal cases were examined in physical examination center as control group. Two groups of fasting serum leptin content were tested and analysed,than on the basis of that they were compared.Result：In the observation group,mild alcoholic fatty liver disease and nonalcoholic fatty liver disease patients of blood thin element were respectively（4.58±0.91）ng/m L and（4.11±1.83）ng/m L; moderate alcoholic fatty liver disease and nonalcoholic fatty liver disease patients of blood thin element were respectively（6.25±1.78）ng/m L and（6.58±2.01）ng/m L; severe alcoholic fatty liver and non alcoholic fatty liver patients of blood thin element were respectively（10.34±2.51）ng/m L and（8.57±1.23）ng/m L; the control of blood thin grain was（3.74±1.93）ng/m L.Mild, medium and severe alcoholic fatty liver disease and nonalcoholic fatty liver disease in patients of blood thin element were significantly higher than the average man,the differences were statistically significant（P〈0.05）.Conclusion：Mild,medium and severe alcoholic fatty liver disease and nonalcoholic fatty liver disease in patients of blood thin element are higher than normal, the level of serum leptin in patients with fatty liver has a direct impact, need to be treated in the clinical intervention.