LSP1基因rs3817198 T>C多态性与乳腺癌易感性的meta分析

LSP1 rs3817198 T > C polymorphism and breast cancer risk by meta-analysis

目的探讨淋巴细胞特异性蛋白1（lymphocyte-specific protein 1,LSP1）基因rs3817198 T〉C多态性与乳腺癌易感性的关系。方法检索Pubmed,Embase和Web of Science数据库,对提取的12个研究结果进行Meta分析。结果 Meta分析结果表明LSP1 rs3817198基因多态性与乳腺癌风险相关（OR=1.07,95%CI 1.05~1.10,P=5.38×10-11）。在所有模型（包括共显性模型、显性模型和隐形模型）中排出GWAS研究后两者也存在相关性。种族和遗传亚组分层分析表明欧洲人群组（OR=1.10;95%CI 1.06~1.14;P=4.19×10-7）和遗传型乳腺癌人群（OR=1.07,95%CI 1.05-1.10,P=1.27×10-8）该位点多态性增加癌症风险。但非洲人群组、亚洲人群组和散发型乳腺癌人群的P值未达到GWAS显著水平。结论 Meta分析表明LSP1基因rs3817198 T〉C多态性可能增加乳腺癌的风险。

Objective To explore the correlation between polymorphism of lymphocyte-specific protein 1 （LSP1） rs3817198 T 〉 C with breast cancer. Methods All eligible case and control studies published were searched out from PubMed, Embase, Web of Science databases. Meta analysis was performed for previous research results from 12 published studies. Results Significantly elevated breast cancer risk was associated with rs3817198 risk allele when all studies were pooled into the meta-analysis （ OR = 1.07 ; 95% CI 1.05 - 1.10, P = 5.38 × 10^-11 ）. Significant results were also found in any model （co-dominant, dominant, or recessive model） for this polymorphism when excluding all GWAS. In the subgroup analysis by ethnicity and hereditary history, significantly increased risks were also found for this polymorphism in Europeans or family history patients （OR = 1.10, 95% CI 1.06 - 1.14, P =4. 19 × 10^-7; OR = 1.07, 95% CI 1.05 - 1.10, P = 1.27 ×10^-8, respectively）. But for Africans and Asians or sporadic breast cancer patients, the P value of meta-analysis didn＇ t reach the GWAS significant level. Conclusion rs3817198 polymorphism in LSP1 is associated with elevated breast cancer risk.