甲状腺功能减退对稳定性心绞痛患者发生房颤的影响

Association Between Hypothyroidism and Incidence of Atrial Fibrillation in Patients with Stable Angina

目的：甲状腺功能减退对稳定性心绞痛患者发生房颤的影响。方法纳入2012年1月至2014年9月经我院收治的稳定性心绞痛患者为研究对象567例,根据患者血浆中 TSH 水平分成3组,即 TSH〈0.55 mIU/ L 组、0.55~4.78 mIU/ L组和〉4.78 mIU/ L 组。比较3组患者的实验室检查结果,并观察不同组别患者的房颤发生率。结果567例稳定性心绞痛患者中,44例诊断为阵发性或持续性房颤,发生率为7.8%。 TSH 在0.55~4.78 mIU/ L 时房颤发生率最低,为6.4%（30/503）；TSH〉4.78 mIU/ L 时发生率最高,为19.5%（8/41）,而 TSH 在〈0.55 mIU/ L 时房颤发生率为17.4%（4/23）,组间比较差异有统计学意义（P〈0.05）。结论甲状腺功能减退与稳定性心绞痛患者发生房颤存在相关性。

Objective To explore the correlation between hypothyroidism and incidence of atrial fibrillation in patients with sta-ble angina. Methods Patients with stable angina with thyroid function test results from 2012 January to 2014 September were includ-ed in this analysis （n=567）. We divided patients into 3 subgroups according to TSH levels：〈0. 55 mIU/ L,0. 55 ~ 4. 78 mIU/ L,〉4. 78 mIU/ L. General clinical data and related biochemical parameters were analyzed. Results A total of 44 patients were diagnosed with AF（7. 8% ）. While the,concentration of TSH is 0. 5 ~ 4. 78 mIU/ L,Atrial fibrillation,incidence rate,for a minimum of 6. 4%（30 / 503）; TSH 〉 4. 78 mIU/ L rate as high as 19. 5% （8 / 41）, and TSH in 〈0. 55 mIU / L when the incidence of atrial fibrillation was 17. 4% （4 / 23）, the difference between groups was statistically significant （P=0. 001）. Conclusion There was correlation be-tween Hypothyroidism and atrial fibrillation patients with stable angina.