疏肝益阳胶囊治疗肝郁肾虚型弱精子症的临床研究

Shugan Yiyang Capsules for the treatment of asthenospermia: A clinical study

目的:观察疏肝益阳胶囊治疗弱精子症的临床疗效及作用机制。方法:135例弱精子症患者随机分为A、B、C 3组,分别给予疏肝益阳胶囊、左卡尼汀口服液以及两药联合治疗,并观察治疗前后精子质量以及精浆α-葡糖苷酶改善情况。结果:A组47例,显效16例,有效17例,无效14例,总有效率为70.21%;B组45例,显效15例,有效16例,无效14例,总有效率为68.89%;C组43例,显效16例,有效20例,无效7例,总有效率为83.72%;C组疗效优于其他两组(P<0.05)。3组均能改善精子质量与精浆α-葡糖苷酶水平,联合用药效果较好。结论:疏肝益阳胶囊可用于治疗弱精子症,和左卡尼汀口服液联合服用可以增效。

Objective： To observe the clinical efficacy of Shugan Yiyang Capsules in the treatment of asthenospermia and its action mechanisms. Methods： We randomly assigned 135 asthenospermia patients to groups A（ n = 47）,B（ n = 45）,and C（ n =43） to be treated with Shugan Yiyang Capsules,oral levocarnitine,or combination of the two. We observed sperm quality and the level of α-glucosidase in the seminal plasma before and after medication. Results： The total effectiveness rate was 70. 21% in group A（ markedly effective in 16 cases and effective in 17）,68. 89% in group B（ markedly effective in 15 cases and effective in 16）,and83. 72% in group C（ markedly effective in 16 cases and effective in 20）,significantly higher in C than in A and B（ P〈0. 05）. Both sperm quality and the level of α-glucosidase in the seminal plasma were improved in the three groups of patients,most obviously in group C. Conclusion： Shugan Yiyang Capsules can be used for the treatment of asthenospermia,and its effect can be enhanced in combination with oral levocarnitine.