前列腺特异性抗原前体及其相关参数在前列腺癌诊断中的研究进展

Pro-prostate-specific antigen and its related indexes in the diagnosis of prostate cancer

前列腺特异性抗原前体(pro PSA)是前列腺特异性抗原(PSA)的前体蛋白,是游离PSA(f PSA)的一种形式。近年来,人们对pro PSA及其相关参数在前列腺癌(PCa)诊断中的意义及其临床应用价值进行了大量的研究,并取得了很大进展。pro PSA相关参数包括pro PSA百分比(%p PSA)、p2PSA、%p2PSA、前列腺健康指数(PHI)等,这些指标在PCa诊断中的作用明显优于血清总PSA(t PSA)和f PSA,特别是%p2PSA和PHI可以显著提高对PCa的检测和鉴别能力,降低不必要的穿刺活检率。本文就pro PSA及其相关检测指标在PCa诊断中应用的研究进展作一综述。。

Pro-prostate-specific antigen（ pro PSA） is the precursor of PSA and a form of free PSA（ f PSA）. In recent years,a lot of studies have been done on pro PSA,the roles of its related indexes in the diagnosis of prostate cancer,and the value of its clinical application. The correlated indexes of pro PSA include pro PSA,% p PSA,p2 PSA,% p2 PSA and prostate health index（ PHI）. They are more effective than total PSA（ t PSA） and f PSA in the diagnosis of prostate cancer,especially % p2 PSA and PHI,which may significantly increase our ability to detect and identify PCa and lower the rate of unnecessary biopsies. This article presents an overview on the advances in the studies of pro PSA and the application of its related indexes in the diagnosis of prostate cancer.