根治性前列腺切除术和放射疗法治疗高危前列腺癌的研究进展

Radical prostatectomy and radiation therapy for high-risk prostate cancer: An update

目前,临床上对高危前列腺癌（PCa）的定义尚未统一,但其中D＇Amico危险分层系统更为学界所接受。其对高危PCa的定义为PSA〉20μg/L,Gleason评分8~10分,临床分期≥T2c。由于高危PCa在治疗后易复发和转移,因此选择合适的治疗方案成为关键。目前针对高危PCa最重要的一线治疗方法为根治性前列腺切除术（RP）或放射治疗（RT）,然而其最佳治疗方案仍未达成共识。本文综述RP和RT治疗高危PCa的研究进展。

Recently,the D＇Amico classification system is widely used for the risk stratification of prostate cancer（ PCa）,although no consensus has been reached for the definition of high-risk PCa. This system defines high-risk PCa as a prostate-specific antigen（ PSA） level 20 ng / ml,a Gleason score of 8- 10,or a clinical stage ≥ T2 c. Because high-risk PCa is prone to recurrence and metastasis after treatment,a proper initial therapy plays a crucial role. Currently,radical prostatectomy and radiation therapy are considered to be two most important options for the initial treatment of high-risk PCa although it remains controversial which is better.