摘要
微管是细胞骨架的重要组成成分,其在细胞内的动态调节关系着细胞正常生理功能的发挥和维持.目前发现多种参与细胞内微管组装与解聚调控的蛋白,其中发挥微管解聚功能的Kinesin-13驱动蛋白家族被广泛地研究,该蛋白具有控制有丝分裂,调控纤毛组装与解聚和神经轴突发育与修复等功能.本文主要对Kinesin-13微管解聚机制,以及在主要的模式生物中生物学功能与调控机制进行比较与分析.
Microtubules are important component of cytoskeletons. Dynamic regulations of microtubules are related to cellular physiological processes. Recently, there are many proteins underlying microtubules assembly or disassembly, in which Kinesin-13s subfamily is widely studied. It is reported that these kinesins play a key role in control of mitosis, regulation of cilia and axonal growth and pruning. In this review, we will discuss the depolymerizing mechanisms of Kinesin-13, and comparison and analysis of Kinesin-13's biological functions and regulations in different model organisms.
出处
《科学通报》
EI
CAS
CSCD
北大核心
2015年第20期1896-1905,共10页
Chinese Science Bulletin
基金
江苏师范大学博士学位教师科研支持项目(13XLR030)
江苏高校优势学科建设工程(PAPD)资助