线粒体蛋白质组学在心血管疾病中的改变及意义

Changes of mitochondrial proteome in cardiovascular disease

线粒体产生的ATP是细胞能量的来源,线粒体是包含约1 000种蛋白质的最重要的细胞器之一。这些蛋白形成线粒体蛋白质功能网(mitochondrial protein functional network),在细胞能量代谢、脂肪酸代谢、细胞信号传导、细胞凋亡与自噬等途径中发挥着重要作用。另外,线粒体功能失调与多种心血管疾病的发生、发展密切相关,线粒体蛋白质组在其中扮演了不可缺少的角色。本文综述线粒体蛋白组学在常见心血管疾病中的研究进展及其意义。

Mitochondria, containing - 1 000 different proteins, are the source of energy are one of the most complex subcellular organelles. The proteins forming the functional network play indispensable roles in energy production, fatty acid metabolism, cell signaling, for a cell and mitochondrial cell apoptosis and autophagy. Mitoehondrial dysfunction is closely related to the occurrence and progression of cardiovascular disease. In this article we focus on the cardiac mitochondrial proteome, with emphasis on the changes associated with cardiovascular disease .