CEACAM6和FOXP3对胰腺癌肿瘤浸润淋巴细胞及预后的影响

The effects of CEACAM6 and FOXP3 on tumor infiltrating lymphocytes and prognosis in patients with pancreatic cancer

目的探讨胰腺癌组织中癌胚抗原相关黏附分子6(CEACAM6)和叉头盒P3(FOXP3)的表达对患者免疫功能及预后的影响。方法采用免疫组织化学法检测40例胰腺癌组织中CEACAM6、FOXP3和CD3、CD8、CD45RO的表达,并分析其与临床病理特征及预后的关系。结果胰腺癌CEACAM6的强阳性率为50%,FOXP3的强阳性率为60%。Ⅲ、Ⅳ期胰腺癌组织中CEACAM6和FOXP3的强阳性率较高,CEACAM6的高表达与CD8和CD45RO细胞的阳性率呈负相关。FOXP3在病理为低分化胰腺癌中强阳性率较高。FOXP3的表达与CD3、CD8、CD45RO阳性T细胞的浸润呈负相关。高表达CEACAM6和FOXP3患者的生存期较短。结论 CEACAM6和FOXP3与胰腺癌的恶性程度有关,其表达对胰腺癌中的肿瘤浸润T细胞具有抑制作用。

Objective To investigate the expressions of carcinoembryonic antigen-related cell adhesion molecule 6（CEACAM6） and forkhead box P3（ FOXP3） on tumor infiltrating lymphocytes and prognosis in patients with pancreatic cancer. Methods The expressions of CEACAM6,FOXP3,CD3,CD8,CD45 RO in pancreatic cancer tissues of 40 cases were assessed by immunohistochemistry,and their relationships with clinicopathological features and prognosis were also analyzed. Results The strong positive rates of CEACAM6 and FOXP3 in pancreatic cancer tissues were 50% and 60%,respectively. The higher strong positive rate were observed in stage Ⅲ and Ⅳ. High expression of CEACAM6 was negatively correlated with the positive rates of CD8 and CD45 RO cells. The strong positive rate of FOXP3 was higher in poorly differentiated pancreatic cancer,and its expression was negatively correlated with the positive rates of CD3,CD8 and CD45 RO cells. The patients which had higher expressions of CEACAM6 and FOXP3 had a shorter survival time. Conclusion CEACAM6 and FOXP3 are associated with the malignant degree of pancreatic cancer. The tumor with higher levels of CEACAM6 and FOXP3 shows inhibited T lymphocyte infiltration.