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miR-1284过表达增加胃癌耐药细胞的药物敏感性及机制 被引量：2

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摘要 胃癌细胞的多药耐药性常常是导致化疗失败的主要原因。小RNA（microRNA,miRNA）为调节基因转录的重要因子,miR-15b和miR-16在胃癌多药耐药SGC-7901/VCR细胞中低表达,通过上调miR-15b和miR-16,可靶向抑制抗凋亡蛋白Bcl-2,进而部分逆转细胞的多药耐药表型[1]。Chen等[2]使用miRNA芯片检测结果表明,
作者 詹泽栩 韦尉元 曹稳珑 张笑石 余唅 谢玉波 肖强
机构地区 广西医科大学第一附属医院胃肠腺体外科 广西医科大学第一附属医院麻醉科
出处 《细胞与分子免疫学杂志》 CAS CSCD 北大核心 2015年第9期1242-1245,共4页 Chinese Journal of Cellular and Molecular Immunology
基金 广西科学技术攻关项目(桂科攻14124004-1-9)
关键词 miR-1284 SGC-7901/VCR细胞 耐药 JAGGED1 NOTCH1 核因子ΚB 生物信息学
分类号 R735.2 [医药卫生—肿瘤] Q279 [生物学—细胞生物学]
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参考文献24

  • 1Xia L, Zhang D, Du R, et al. miR-15b and miR-16 Imdulate multidrug resistance by fingering BCL2 in human gastric cancer cells [ J ]. Int J Cancer, 2008, 123(2) : 372 -379.
  • 2Chen W, Tang Z, Sun Y, et al. miRNA expression profde in primary gastric cancers and paired lymph node metastases indieates that miR-lOa plays a role in metastasis from prinmry gastric cancer to lymph nodes[J]. Exp Ther Med, 2012, 3(2) : 351 -356.
  • 3Patnaik SK, Yendamuri S, Kannisto E, et al. microRNA expression profiles of whole blood in lung adenocareinoma[ J/OA]. PLoS One, 2012, 7(9) : e46045.
  • 4Lv L, Deng H, Li y, et al. The DNA lmthytafion-regulated miR-193a-3p dictates the multi-chemoresistance of bladder cancer v/a repression of SRSF2/PLAU/HIC2 expression[J/OL]. Cell Death Dis, 2014, 5: e1402.
  • 5Ma L, Mao R, Shen K, et al. Atractylenolide I -mediated Notch pathway inhibition attenuates gastric cancer stem cell traits [ J ]. Biochem Biophys Res Commun, 2014, 450 (1) : 353 -359.
  • 6Zhang J ,Zhang Hd,Chen L,et al.β-elemene reverses chemoresistance of breast cancer via regulating MDR-related microRNA expression [ J ].Cell Physiol Biochem, 2014, 34:2027-2037.
  • 7Cenciarelli C, Marei HE, Zonfrillo M, et al. PDGF receptor alpha inhibition induces apoptosis in glioblastoma cancer stem cells refractory to anti-Notch and anti-EGFR treatment [ J/OL ]. Mol Cancer, 2014, 13: 247.
  • 8Du X, Zhao YP, Zhang TP, et al. Alteration of the intrinsic apoptosis pathway is involved in Notch-induced chemoresistance to gemcitabine in pancreatic cancer[J]. Arch Med Res, 2014, 45(1) : 15 -20.
  • 9Chen Z, Zhang L, Xia L, et al. Genomic analysis of drug resistant gastric cancer cell lines by combining mRNA and microRNA expression prof'ding [ J ]. Cancer Lett, 2014, 350 ( 1/2 ) : 43 - 51.
  • 10Zhou W, Fu XQ, Zhang LL, et al. The AKT1/NF-kappaB/Notchl/ PTEN axis has an important role in chemoresistance of gastric cancer cens[J/OL]. Cell Death Dis, 2013, 4: e847.

二级参考文献16

  • 1Allison DC,Carney SC, Ahlmann ER, et al. A Meta-analysis of osteo- sarcoma outcomes in the modem medical era [ J]. Sarcoma, 2012, 2012:704872.
  • 2Longhi A,Errani C, De Paolis M,et al. Primary bone osteosarcoma in the pediatric age : state of the art[ J]. Cancer Treatment Rev ,2006,32 (6) :423-436.
  • 3Blaumueller CM, Qi H, Zagouras P, et al. Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane[ J]. Cell, 1997,90 ( 2 ) : 281-291.
  • 4Arias AM, Zeechini V, Brennan K. CSL-independent Notch signal- ling:a checkpoint in cell fate decisions during development? [ J]. Curr Opin Genet Develop,2002,12(5 ) :524-533.
  • 5Mu X,Isaac C,Greco N,et al. Notch signaling is associated with AL- DH activity and an aggressive metastatic phenotype in murine osteo- sarcoma cells[ J]. Front Onco1,2013,3 : 143.
  • 6Masuda S, Kumano K,Suzuki T,et al. Dual antitumor mechanisms of Notch signaling inhibitor in a T-cell acute lymphoblastic leukemia xenograft model[ J]. Cancer Sci ,2009,100( 12 ) :2444-2450.
  • 7Grabher C,Harald yon Boehmer A. Notch 1 activation in the molecuz lar pathogenesis of T-cell acute lymphoblastic leukaemia[ J ]. Nat Rev Cancer ,2006,6 ( 5 ) :347-359.
  • 8Pear WS, Aster JC. T cell acute lympbob|astic leukemia/lymphoma : a human cancer commonly associated with aberrant NOTCH1 signaling [J], CmT Opin Hematnl,200d-, I I (6) :426-33.
  • 9Nefedoval Y,Sullivanl DM,Bolickl SC,et al. Inhibition of Notch sig- naling induces apoptosis of myeloma cells and enhances sensitivity to chemotherapy [ J ]. Blood,2008,111 (4) : 2220-2229.
  • 10Curry CL, Reed LL, Golde TE, et al. Gamma secretase inhibitor blocks Notch activation and induces apoptosis in Kaposi' s sarcoma tumor cells [ J 1- Oncogene, 2005,24 ( 42 ) : 6333 -6344.

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细胞与分子免疫学杂志
2015年 第9期

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