2型糖尿病伴阻塞性睡眠呼吸暂停低通气综合征的临床特点和蛋白羰基水平分析

Clinical features,levels of protein carbonyl in serum of obstrucitive sleep apnea syndrome with type 2 diabetes mellitus

目的:观察2型糖尿病中阻塞性睡眠呼吸暂停低通气综合征(OSAHS)的患病情况,临床特点及血清蛋白羰基水平。方法:选择2型糖尿病患者203例,进行多导联睡眠呼吸监测,记录AHI、年龄、身高、体重指数(BMI)、腰围、糖尿病病程,测定空腹血糖、糖化血红蛋白(HbA1c)、血清蛋白羰基(PCO)水平。结果:2型糖尿病患者中OSAHS患病率为79.2%,其中重度30.4%,中度45.4%,轻度24.2%。伴OSAHS患者的BMI、腰围、空腹血糖、HbA1c及血清PCO水平均高于未合并OSAHS者,差别有统计学意义(P<0.01)。回归分析发现HbA1c与OSAHS患病风险呈独立正相关(P<0.05,OR=6.11),HbA1c、BMI、腰围、病程、血清PCO水平均与AHI独立正相关,HbA1c为最主要的独立危险因素(P<0.05)。结论:2型糖尿病患者中OSAHS的患病率较高,合并OSAHS的患者血糖控制差,体内蛋白质氧化损伤加重。

Objective：To explore the prevalence,clinical feature and levels of protein carbonyl（PCO）in serum of type 2diabetes mellitus combining obstrucitive sleep apnea syndrome（OSAHS）.Method：Two hundred and three patients with type 2diabetes were taken multi lead sleep detection and their AHI,age,height,body mass index（BMI）,waistline,duration of diabetes,fast blood glucose,HbA1 clevel and level of PCO in serum were recorded.Result：The prevalence of OSAHS was 79.2% in 203 patients,serious apnea 30.4%,moderate apnea 45.4%,mild apnea 24.2%.BMI,waistline,fast blood glucose,HbA1 clevel and level of PCO in serum were higher in patients complicated with OSAHS（P〈0.01）.HbA1 cwas independently and positively correlated with patients with OSAHS risk（P〈0.05,OR6.11）.The independent correlation factors of AHI included HbA1 clevel,BMI,waistline,duration of diabetes and level of PCO in serum,with HbA1 cas the predominant factor（P〈0.05）.Conclusion：The prevalence of OSAHS was higher in patients of type 2diabetes mellitus combining（OSAHS）.Moreover,in these patients poor glucose control and aggravated protein oxidative injury were observed.