药物性肝病的发病类型及保肝药物的作用机制

Drug-induced liver disease:Types and mechanisms of action of liver-protecting drugs

药物性肝病是临床常见的药物不良反应之一,急性肝损伤是药物性肝病最常见的发病形式,少数可发生威胁生命的肝衰竭.药物性肝病的确诊,需要排除其他原因,而患者常常合并使用多种药物,不易判断是何种药物所导致的肝病,且出现临床症状之后,缺乏规范化的治疗.本文将药物性肝病的病理类别与常见保肝药物的作用机制作一综述.

Drug-induced liver disease is one of the adverse reactions of clinical drugs. Acute liver injury is the most common form of drug-induced liver disease and even could cause life-threatening liver failure. It is not easy to diagnose, and the diagnosis can be established only after other diagnoses excluded. In most cases, patients usually are prescribed several drugs together, which makes it even harder to distinguish and give standardized treatment. This review summarizes the pathological category of Drug- induced liver disease and the mechanisms of action of liver-protecing drugs.