非甾体抗炎药相关的药物性肝损伤的研究进展

Nonsteroidal antiinflammatory drug-induced liver injury

非甾体抗炎药(nonsteroidal anti-inflammatory drugs,NSAIDs)在临床上应用非常广泛,目前普遍认为药物性肝损伤是该类药物罕见发生的不良反应,然而涉及的用药患者数量众多,需要引起重视.NSAIDs在药物性肝损伤的药物中位列第2位,仅次于抗菌药物.本文就非甾体抗炎药相关性的药物性肝损伤及重点药物作一综述.

Nonsteroidal anti-inflammatory drugs（NSAIDs） are among the most widely used drugs in clinical practice.It is generally accepted that druginduced liver injury（DILI） is a relatively rare adverse reaction to NSAIDs,however,DILI related to NSAIDs is of outstanding importance as the wide use of these drugs.NSAIDs are the second leading cause of DILI after antimicrobialdrugs.This review presents an overview of current knowledge of NSAID-induced liver injury（N-DILI） with emphasis on the causative drugs.