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乳腺癌中HIF-1α与Ki-67、Caspase-3和VEGF表达的意义 被引量：13

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摘要 目的分析乳腺浸润性导管癌中缺氧诱导因子-1α(hypoxia inducible factor-1α,HIF-1α)表达,探讨其表达与Ki-67、Caspase-3和VEGF表达的关系。方法收集105例乳腺癌手术切除标本,采用免疫组化SP法检测HIF-1α、Ki-67、Caspase-3和VEGF的表达,分析HIF-1α表达与Ki-67、Caspase-3和VEGF表达的关系。结果 HIF-1α的阳性率在乳腺癌组织(68.6%)与淋巴结转移癌组织(77.1%)的差异无统计学意义(P>0.05),但均明显高于正常乳腺组织(17.7%,P<0.05)。同时乳腺癌组织中伴淋巴结转移(65.3%)与无淋巴结转移(71.4%)的HIF-1α阳性率差异无统计学意义(P>0.05)。与HIF-1α阴性组相比,HIF-1α阳性组乳腺癌细胞的Ki-67增殖指数和VEGF表达明显增高,而Caspase-3表达明显降低(P<0.05)。结论乳腺癌中HIF-1α的表达与Ki-67、Caspase-3和VEGF表达密切相关,可能会通过促进肿瘤组织的血管生成,使肿瘤细胞的增殖加快和凋亡减少,为以HIF-1α靶点的临床治疗提供实验基础。
作者 牛海艳 郑艺菲 蓝永洪 蒋洁
机构地区 海南医学院病理学教研室 海南医学院形态学实验室 海南医学院科研部
出处 《临床与实验病理学杂志》 CAS CSCD 北大核心 2015年第7期804-806,共3页 Chinese Journal of Clinical and Experimental Pathology
基金 海南省自然科学基金资助(812194 813249)
关键词 乳腺肿瘤 缺氧诱导因子-1Α KI-67 CASPASE-3 VEGF
分类号 R737.9 [医药卫生—肿瘤]
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参考文献15

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二级参考文献5

共引文献36

同被引文献153

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  • 2Ma J, Zhang Q, Chen S, et al. Mitochondrial dysfunction promotes breast cancer cell migration and invasion through HIFloL accumula- tion via increased production of reactive oxygen species[J]. PLoS One,2013,8(7) : e69485.
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引证文献13

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临床与实验病理学杂志
2015年 第7期

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