期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

CDX2在肝外胆管癌中的表达意义及其与Ki-67的相关性

下载PDF
导出
摘要 目的探讨肝外胆管癌中CDX2的表达,及其与临床病理特征、Ki-67增殖指数之间的相关性。方法应用免疫组化MaxV ision法检测40例肝外胆管癌以及10例非癌胆管组织中CDX2与Ki-67的表达。结果 40例肝外胆管癌中CDX2阳性率(35%,14/40)高于非癌胆管组织(10%,1/10)(P<0.05),CDX2表达与肿瘤分化程度具有相关性(χ2=6.411,P<0.05)。CDX2与Ki-67的表达呈负相关(rs=-0.645,P<0.05)。结论 CDX2可能在肝外胆管癌的发生、发展中发挥作用,其不仅参与肿瘤细胞的分化,也可能通过某种机制调控细胞的增殖。
作者 于雪梅 尹华珍 韩爱华
机构地区 山东省滨州市人民医院病理科
出处 《临床与实验病理学杂志》 CAS CSCD 北大核心 2015年第7期818-819,共2页 Chinese Journal of Clinical and Experimental Pathology
关键词 胆管肿瘤 CDX2 KI-67 免疫组织化学
分类号 R735.8 [医药卫生—肿瘤]
  • 相关文献

参考文献5

  • 1Almeida R, Silva E, Santos-Silva F, et al. Expression of intestine specific transcription factors, CDX1 and CDX2, in intestinal meta- plasia and gastric careinomas[ J ]. J Pathol, 2003,199 (1):36 - 40.
  • 2储婧,秦蓉,王娜娜,王弦,陈满丽,张晖,年建泽.胃癌及癌旁组织中CDX2和claudin-3的表达及其意义[J].临床与实验病理学杂志,2011,27(12):1280-1285. 被引量：6
  • 3Villanacci V, Rossi E, Zambelli C, et al. COX-2, CDX2, and CDC2 immunohistochemical assessment for dysplasia-carcinoma progression in Barrett's esophagus [ J ]. Dig Liver Dis, 2007,39 (4) :305 - 11.
  • 4Bae J M, Lee T H, Cho N Y, et al. Loss of' CDX2 expression is associated with poor prognosis in coloreetal cancer patients [ J ]. World J Gastroenterol, 2015,21 (5) :1457 -67.
  • 5Chang Y T, Hsu C, Jeng Y M, et al. Expression of the caudal- type homeodomain transcription factor CDX2 is related to clinical outcome in biliary tract carcinoma [ J ]. Gastroenterol Hepatol, 2007,22(3) :389 -94.

二级参考文献20

  • 1Almeida R,Silva E,Santos-Silva F,et al.Expression of intestine-specific transcription factors,CDXl and CDX2,in intestinal metaplasia and gastric carcinomas[J].J Pathol,2003,199(1):36-40.
  • 2Furuse M,Tsukita S.Claudins in occluding junctions of humans and flies[J].Trends Cell Biol,2006,l6(4):181-8.
  • 3James R,Erler T,Kazenwadel J.Structure of the murine homeobox gene CDX2.Expression in embryonic and adult intestinal epithelium[J].J Biol Chem,1994,269(21):15229-37.
  • 4Mesquita P,Jonckheere N,Almeida R,et al.Human MUC2 mucin gene is transcriptionally regulated by Cdx homeodomain proteins in gastrointestinal carcinoma cell lines[J].J Biol Chem,2003,278(51):51549-56.
  • 5Hinoi T,Gesina G,Akyol A,et al.CDX2 regulated expression of iron transport protein hephaestin in intestinal andcolonic epithelium[J].Gastroenterology,2005,128 (4):946-61.
  • 6Bai Y Q,Yamnamoto H,Akiyama Y,et al.Ectopic expression of homeodnmain protein CDX2 in intestinal metaplasia and carcinomas of the stomach[J].Cancer Lett,2002,176 (1):47-55.
  • 7Kaimaktchiev V,Terracciano L,Tornillo L,et al.The hnmeohox intestinal diferentiation factor CDX2 selectively expressed in gastrointestinal adenocarcinomas[J].Mod Pathol,2004,17(11):1392-9.
  • 8Mizoshita T.Tsukamoto T,Inada K,et al.Immunohistochemically detectable Cdx2 is present in intestinal phenotypic elements in ear1y gastric cancers of both differentiated and undiferentiated types,with no correlation to non-neoplastic surrounding mucosa[J].Pathol Int,2004,54(6):392-400.
  • 9Mizoshita T,Tsukamoto T,Nakanishi H,et al.Expression of Cdx2 and the phenotype of advanced gastric cancers:relationship with prognosis[J].J Cancer Res Clin Oncol,2003,129(12):727-34.
  • 10Soini Y.Expresion of claudins 1,2,3,4,5 and 7 in various types of tumours[J].Histopathology,2005,46(5):551-60.

共引文献5

临床与实验病理学杂志
2015年 第7期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部