难治性噪声性耳聋鼓室注射甲泼尼龙琥珀酸钠的疗效

Intratympanic methylprednisolone hemisuccinate injection in treating the refractory noise induced deafness

目的探讨鼓室注射甲泼尼龙琥珀酸钠治疗难治性噪声性耳聋患者的疗效。方法2007年12月至2014年10月噪声性耳聋聋患者120例（215耳），分成激素治疗组（107耳）和非激素治疗组（108耳）。两组前期治疗后没有痊愈的患者共145耳，再行甲泼尼龙琥珀酸钠40mg鼓室内注射，20次／1周。结果激素治疗组有效率67．3％（72／107），非激素治疗组有效率65．7％（71／108），两组有效率的差异无统计学意义（χ^=2．058，P〉0．05）。鼓室内注射甲泼尼龙琥珀酸钠总有效率46．2％（67／145），其中激素治疗组有效率为45．1％（32／71），非激素治疗组有效率为47．3％（35/74），两组注射甲泼尼龙琥珀酸钠总有效率的差异无统计学意义（χ^2=0．072，P=0．788）。结论对于前期治疗没有痊愈的难治性噪声性耳聋患者，后期鼓室注射甲泼尼龙琥珀酸钠有明显疗效，且其疗效与前期是否应用激素无关。

Objective To＇analyze the efficacy of Methylprednisolone hemisuccinate intratympanic injection for refractory noise induced deafness. Methods One hundred and twenty cases （215 ears） of noise induced deafness were treated with either hormone group （107 ears） or with non hormone group （108 ears）. Following prior interventions,145 ears went on to receive intratympanic Methylprednisolone hemisuccinate injection twice a week. Results After Intratympanic therapy, the total effective rate was 46.2%. 32 of 71 ears （45.1%）demonstrated hearing improvement in hormone group and 35 of 74 ears （47.3%） in non hormone group. The difference was statistically insignificant （P=0.788）. Conclusion Intratympanic therapy appears to provide additional treatment benefits for patients with refractory noise induced deafness who have been treated with prior interventions. The outcome is not affected by pretreatment with hormone.