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参附注射液对急性心肌梗死溶栓后再灌注损伤的保护作用

Protective effect of Shenfu injection on reperfusion injury after thrombolytic therapy in acute myocardial infarction patients
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摘要 目的:探讨参附注射液(SFI)对急性心肌梗死(AMI)溶栓后再灌注损伤的保护作用。方法:选取AMI患者中溶栓血管再通者80例,随机分为对照组和观察组。对照组仅予常规溶栓治疗,观察组在常规溶栓治疗的同时应用SFI治疗。溶栓后均监测心肌酶谱和心律失常的发生情况。结果:溶栓后,观察组CK、CKMB、LDH、α-HBDH达峰值的时间较对照组明显缩短(P<0.05);观察组ST、SB、AVB、PVB、PVT发生率明显低于对照组(P<0.05或P<0.01),且SB、AVB、PVB的持续时间较对照组明显缩短(P<0.05或P<0.01)。结论:SFI对AMI溶栓后再灌注损伤有显著的保护作用。 Objective:To explore the protective effect of Shenfu injection(SFI)on reperfusion injury after thrombolytic therapy in acute myocardial infarction(AMI)patients.Method:80patients with thrombolytic recanalization from AMI patients were randomly divided into observation group(40cases)and control group(40cases).Two groups were treated by thrombolytic therapy,and those in control group were also treated with SFI.After thrombolytic therapy,the changes of myocardial enzyme and the occurrence of arrhythmia were observed.Result:After thrombolytic therapy,the time of CK,CKMB,LDH,α-HBDH to peak in the observation group were shorter than that of control group(P〈0.05).The incidence rate of ST、SB、AVB、PVB、PVT in the observation group were lower than that of control group(P〈0.05 or P〈0.01),and the duration of SB、AVB、PVB were shorter than that of control group(P〈0.05 or P〈0.01).Conclusion:SFI exerted good protective effect on reperfusion injury after thrombolytic therapy in AMI patients.
作者 王玉杰
出处 《临床急诊杂志》 CAS 2015年第7期496-498,共3页 Journal of Clinical Emergency
关键词 参附注射液 急性心肌梗死 溶栓 再灌注损伤 Shenfu injection acute myocardial infarction thrombolysis reperfusion injury
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