白细胞介素-17与原发性肾病综合征相关性实验研究

Experimental research of correlation between interleukin-17 and primary nephrotic syndrome

目的探讨白细胞介素-17(IL-17)与原发性肾病综合征(PNS)的相关性。方法采用酶联免疫吸附试验(ELISA)检测35例PNS患者(肾病综合征组)和36例健康体检者(对照组)外周静脉血IL-17水平,比较两组IL-17水平均数,再对肾病综合征组外周静脉血IL-17与其尿蛋白水平进行直线相关分析。结果肾病综合征组外周静脉血IL-17高于对照组[(50.77±7.16)ng/L VS(33.83±6.23)ng/L],差异有统计学意义(t=10.52,P<0.01);肾病综合征组外周静脉血IL-17与其尿蛋白水平呈直线正相关(r=0.72,P<0.01)。结论原发性肾病综合征的发病可能与体内IL-17水平的异常存在相关性。

Objective To investigate correlation between interleukin-17（IL-17） and primary nephrotic syndrome（PNS）. Methods Enzyme-linked immuno sorbent assay（ELISA） was applied for detecting IL-17 levels in peripheral venous blood of 35 PNS patients（nephrotic syndrome group） and 36 healthy people（control group）. IL-17 meal levels were compared between the two groups. Linear correlation analysis was made on IL-17 level in peripheral venous blood of nephrotic syndrome patients and their urinary protein level. Results The nephrotic syndrome group had much higher IL-17 level in peripheral venous blood than the control group [（50.77±7.16） ng/L VS（33.83±6.23） ng/L], and their difference had statistical significance（t=10.52, P〈0.01）. IL-17 level in peripheral venous blood of nephrotic syndrome patients had positive linear correlation with their urinary protein level（r=0.72, P〈0.01）. Conclusion Morbidity of primary nephrotic syndrome may have correlation with abnormal IL-17 level.