血清BNP水平和药物干预在脑卒中患者继发左室舒张功能不全中的临床研究

Clinical Study of Serum BNP Level and Drug Intervention in Left Ventricular Diastolic Dysfunction in Patients With Cerebral Apoplexy

目的分析药物干预对脑卒中患者继发左室舒张功能不全的影响。方法 205例脑卒中后左室功能不全患者分为试验组和对照组。对照组103例,用ARB加β2受体阻滞剂,试验组102例在对照组基础上加用醛固酮拮抗剂,对比分析两组患者的治疗效果。结果两组患者治疗后血清BNP均下降,但试验组下降更为明显,治疗后血压较治疗前下降,LEVF及E/A值较治疗前提高,差异均具有统计学意义(P<0.05)。结论三药方案对患者及时诊断和有效治疗具有重要意义。

Objective To discuss the effect of drug intervention on left ventricular diastolic dysfunction in patients with cerebral apoplexy.Methods 205 patients with left ventricular dysfunction after stroke were divided into test group and control group, 103 cases in control group received ARB and β2-blocker, 102 cases in test group accepted ARB、β2-blocker and aldosterone antagonist. To compare and analyze treatment effect between two groups.Results After treatment, serum BNP of two groups were significantly decreased,but test group decreased more significantly. Blood pressure was decreased, LEVF and E/A were significantly increased compared with before treatment,differences had statistical significance（P 〈 0.05）.ConclusionThree drug regimens for patients with timely diagnosis and effective treatment has important significance.