孕妇血清中FT_4,TSH和TPO的检测

Detection of Serum FT_4, TSH and TPO in Pregnant Women

目的检测孕妇血清中的FT_4、TSH、TPO,并探讨孕妇血清中游离FT_4、TSH和TPO水平与妊娠结局的相关性。方法将TSH升高伴FT_4下降的孕妇定义为甲减组,TSH、FT4正常的孕妇定义对照组,比较两组TSH、TPOAb及FT_4水平和妊娠结局。结果甲减组和对照组TSH、TPOAb及FT_4水平结果比较有差异(P<0.05);甲减组妊娠高血压、早产、低体重儿、胎儿贫血的发生率高于对照组(P<0.05)。结论本次研究认为妊娠合并甲状腺功能减退与不良妊娠结局相关,有必要在妊娠期联合检测FT_4,TSH和TPOAb,并对异常的孕妇进行积极的干预。

Objective To detect serum FT4, TSH, TPO of pregnant women, discuss the relationship between serum FT4, TSH ,TPO and pregnancy outcome. MethodsTSH increased with the decrease of FT4 defined hypothyroidism group, and FT4, TSH normal defined control group. To compare the levels of FT4, TPOAb and TSH and outcome of pregnancy.Results TSH, TPOAb and FT4 level between hypothyroidism group and control group had significant difference（P 〈 0.05）. Gestational hypertension, premature birth and low birth weight infants, incidence of fetal anemia of hypothyroidism group were significantly higher than control group（P 〈 0.05）.Conclusion In this study, the hypothyroidism of pregnancy was significantly related to the adverse pregnancy outcome, it is necessary for joint detection of FT4, TSH and TPOAb, and to carry out active intervention on the abnormal pregnant women.