醒脑静注射液治疗脓毒症相关脑病的临床观察

Treatment of Sepsis-associated Encephalopathy by Xingnaojing Injection: a Clinical Observation

目的观察醒脑静注射液对脓毒症相关脑病（sepsis-associated encephalopathy,SAE）患者的临床疗效。方法回顾性分析2010年9月—2013年9月北京大学人民医院EICU收治的65例SAE患者的临床资料,根据是否应用醒脑静注射液治疗分为治疗组（33例）及对照组（32例）。对照组予抗感染、对症支持等常规治疗,治疗组在此基础上联合醒脑静注射液（20 m L/天）静脉滴注,应用7~10天。观察两组退热时间、Glasgow意识障碍昏迷评定量表（Glasgow coma scale,GCS）评分、C-反应蛋白（C-reactive protein,CRP）、神经元特异性烯醇化酶（neuron-specific enolase,NSE）含量及脑电图的改善情况。结果与对照组比较,治疗组治疗后退热时间较短,CRP水平下降,GCS评分及脑电图疗效均明显改善,差异均有统计学意义（P〈0.05）。用药期间未发生不良反应。结论醒脑静注射液对脓毒症相关性脑病治疗较安全、有效。

Objective To observe the efficacy of Xingnaojing Injection（ XI） in treatment of sepsis-associated encephalopathy（ SAE）. Methods Totally 65 SAE patients were retrospectively analyzed at EICU from September 2010 to September 2013. They were assigned to the control group（ 32 cases） and the treatment group（ 33 cases） according to whether they received XI. Patients in the control group received anti-infection and symptomatic support,while those in the treatment group were intravenously injected with XI at 20 m L per day for additional 7- 10 days. The fever clearance time,Glasgow coma scale（ GCS）,C-reactive protein（ CRP）,neuron-specific enolase（ NSE）,and improvement of electroencephalogram（ EEG） were observed in the two groups. Results Compared with the control group,the fever clearance time was shortened,CRP levels decreased,GCS score and efficacy of EEG was alleviated in the treatment group after treatment with statistical difference（P〈0. 05）. No adverse reaction occurred during medication. Conclusion XI was safe and effective in treatment of SAE.