清肺消痰解痉汤联合沙丁胺醇气雾剂治疗哮喘

Qingfei Xiaotan Jiejing Decoction with Salbutamol Aerosol in Treating Asthma

目的:对清肺消痰解痉汤联合沙丁胺醇气雾剂对支气管哮喘的临床疗效进行探讨。方法:选取达州市中心医院2010年2月—2014年5月收治的128例支气管哮喘(寒哮)患者作为研究对象,随机分为观察组和对照组,每组各64例。两组患者均给予常规沙丁胺醇气雾剂,100μg/次,每日4次,观察组患者则在此基础上加以口服中药清肺消痰解痉汤,每日1剂,分早晚2次温服。两组患者分别于治疗前和治疗12周后对其肺通气功能,最大呼气峰流速(peak expiratory flow,PEF),哮喘控制测试评分(asthma control test score,ACT)及中医证候积分进行检测和评价,并结合上述结果对其临床疗效进行比较分析。结果:治疗后两组患者各项观察指标均较治疗前有明显改善,其中观察组患者相比对照组患者第一秒用力呼气容积(forced expiratory volume in one second,FEV1),PEF及ACT评分明显升高,中医证候积分明显降低,且观察组临床控制率较对照组明显提高,而无效率则明显降低,差异均具有统计学意义。结论:清肺消痰解痉汤联合沙丁胺醇可有效改善支气管哮喘发作期(寒哮)患者的肺通气功能,缓解其临床症状,提高临床控制率,相比单一的沙丁胺醇气雾剂治疗疗效更佳。

Objective： To study the efficacy of Qingfei Xiaotan Jiejing decoction with salbutamol aerosol in treating asthma. Method： Altogether one hundred and twenty-eight patients with bronchial asthma（ cold asthma） treated in our hospital from February 2010 to May 2014 were selected as the study objects and randomly divided into the observation group and the control group,with 64 cases in each group. Both groups of patients were given regular salbutamol aerosol with the dose of 100 μg / time,twice in the morning and evening. On that basis,the observation group is orally given traditional Chinese medicine Qingfei Xiaotan Jiejing decoction,one dose a day,taken warm in the morning and evening. Patients of the two groups were tested for their lung ventilation function,peak expiratory flow（ PEF）,asthma control test score（ ACT） and traditional Chinese medicine（ TCM）symptoms integral before the treatment and at the 12 thweek after the treatment. A comparative analysis was made for its clinical efficacy according to the above results. Result： Various observation indexes in both groups were obviously improved after treatment compared with that before the treatment. Specifically,compared with the control group,the observation group showed significantly increase in forced expiratory volume in one second（ FEV1）,PEF,ACT,clinical control rate and notable decrease in TCM syndrome integrals and inefficiency,with statistical differences. Conclusion： Qingfei Xiaotan Jiejing decoction combined salbutamol aerosol can effectively improve the pulmonary ventilation function,relieve the clinical symptoms and enhance the clinical control rate of patients with bronchial asthma（ cold asthma）,with a better efficacy than the single administration of salbutamol aerosol.