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帕瑞肽治疗库欣病的研究进展 被引量:1

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摘要 库欣病是垂体促肾上腺皮质激素(adrenocomcotrophic hormone,ACTH)腺瘤或ACTH细胞增生,导致分泌过多ACTH,而引起肾上腺皮质增生,产生皮质醇增多症导致的一系列物质代谢紊乱和病理变化,临床上表现为库欣综合征。如果得不到有效地治疗,库欣病的致残率和病死率非常高。库欣病首选经蝶窦手术切除治疗,但是由于大部分垂体ACTH腺瘤是微腺瘤,还有部分库欣病的垂体MRI检查没有明确的肿瘤,造成手术全切比较困难,术后缓解率低,长期随访发现术后复发率可高达25%~46%。
出处 《中华神经外科杂志》 CSCD 北大核心 2015年第7期745-746,共2页 Chinese Journal of Neurosurgery
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