摘要
外泌体是一种由多种活细胞分泌到细胞外直径为40-100 nm的囊泡小体,其内容物含蛋白质、脂质和核酸等。消化系统肿瘤是人类常见的恶性肿瘤之一,其中胃癌、胰腺癌和结直肠癌等的发病率和死亡率较高。外泌体作为肿瘤学研究的热点,其在消化系统肿瘤发生、发展、临床诊断和治疗方面具有重要的研究价值。本文对外泌体的生物合成、组成成分及其在消化系统肿瘤中的研究进展进行综述。
Exosomes are small vesicular bodies of 40-100 nm secreted by various types of living cells into the extracellular environment,and contain proteins,lipids and nucleic acids.Gastrointestinal tumor is one of the most common malignant tumor.The morbidity and mortality of gastric cancer,pancreatic cancer and colorectal cancer are high among malignant tumors.As a hotspot in the research of oncology,exosomes have potential values in the research of development,diagnosis and treatment of human gastrointestinal tumor.This review summarizes the biogenesis and components of exosomes as well as the progression of exosomes in human gastrointestinal tumor.
出处
《肿瘤》
CAS
CSCD
北大核心
2015年第7期810-815,共6页
Tumor
关键词
消化系统肿瘤
生物合成途径
诊断
治疗
外泌体
Digestive system neoplasms
Biosynthetic pathways
Diagnosis
Therapy
Exosomes
