维吾尔族及汉族非酒精性脂肪肝与代谢综合征共有因素的相关性分析

Analysis of the common factors between non-alcoholic fatty liver disease and metabolic syndrome in Uygur population and Han population

目的探讨非酒精性脂肪肝(NAFLD)与代谢综合征(MS)等共有因素的相关性,为预防和控制NAFLD和MS的发生发展提供依据。方法选择2013年6月至2014年6月在新疆医科大学第一附属医院健康体检人群3 879人作为研究对象,共分为两组,其中符合NAFLD临床诊断标准的1 039例患者为NAFLD组,非NAFLD组为2 840例。对研究对象进行问卷调查、一般体格检查、生化指标测定,分析维吾尔族、汉族不同年龄人群的NAFLD与MS检出率,采用Spearman相关性分析对NAFLD和MS共有因素进行分析。结果 NAFLD汉族检出率为25.1%,维吾尔族为32.3%;MS总检出率为8.8%,其中汉族检出率为8.0%,维吾尔族为11.6%。维吾尔族人群NAFLD和MS检出率均高于汉族,差异均有统计学意义(P<0.01)。两个民族人群中NAFLD组体质指数(BMI)、血压、空腹血糖(FPG)、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、天冬氨酸转氨酶(AST)、丙氨酸转氨酶(ALT)均高于非NAFLD组,高密度脂蛋白胆固醇(HDLC)低于非脂肪肝组,差异均有统计学意义(P<0.01);NAFLD检出率随年龄增长而增高,差异有统计学意义(P<0.01),NAFLD与超重、血糖升高、高血压、高血脂等MS组分呈显著相关性(P<0.01)。结论 NAFLD与MS密切相关,二者相互加重、相互促进,应当予以重视并进行防治。

Objective To explore the correlation of the common factors between non-alcoholic fatty liver disease （NAFLD） and metabolic syndrome （MS）, and to provide the basis for prevention and control of NAFLD and progression of MS. Methods During June of 2013 to June of 2014, 3 879 cases were selected from people who were physically examined in the First Affiliated Hospital of Xinjiang Medical University as the subjects. All subjects were divided into NAFLD group （ 1 039 cases） and non- NAFLD group （2 840 cases ）. The investigation was performed by questionnaire, physical examination and biochemical indicator detection to analyze the morbidities of NAFLD and MS in different age subgroups of Han population and Uygur population. The Spearman correlation analysis was used to evaluate the correlation the common factors between NAFLD and MS. Results The detection rates of NAFLD in Han population and Uygur population were 25.1% and 32.3%; respectively. The total detection rate of MS was 8.8%, the detection rates of MS in Han population and Uygur population were 8.0% and 11.6%, respectively. The detection rates of NAFLD and MS in Uyghur population were significantly higher than those in Hart population （P〈0.01）. The levels of body mass index （BMI）, blood pressure, fasting plasma glucose （FPG）, triglyceride （TG）, total cholesterol （TC）, low density lipoprotein cholesterol （LDL-C）, alanine aminotransferase （AST） and aspartate aminotransferase （ALT） of NAFLD groups were significantly higher than non-NAFLD groups in Hart population and Uygur population （P〈0.01）. The levels of high density lipoprotein cholesterol （HDL-C） of NAFLD groups were significantly lower than those of non NAFLD groups in Han population and Uygur population （P〈0.01）. The detection rate of NAFLD increased with age （P〈0.01）. There was significant correlation between NAFLD and indexes of MS （such as overweight, increased blood glucose, hypertension and hypeflipidemia and so on）（P〈0.01 ）. Conclusion NAFLD is related closely to MS, NAFLD and MS could mutually promote and aggravate. The measures of preventing and treating NAFLD and MS should be taken.