血管重塑机制研究进展

Pathogenesis of the vascular remodeling

血管重塑是改善缺血性疾病治疗预后的瓶颈,包括血管壁细胞和细胞外基质结构和形态变化。血流动力学变化通过机械转导机制激活一系列血管生物化学信号,内皮细胞分泌血管活性物质和细胞因子,平滑肌细胞分泌生长因子,可激活多种信号转导途径,通过调控基因表达使血管发生增殖、凋亡、迁移、炎性反应,以及细胞外基质分泌、沉积与降解等变化。本文综述了细胞因子和细胞周期调控蛋白参与血管重塑的研究现状,以及microRNA在调控细胞表型转换、调控炎性反应和调控细胞增殖等方面参与血管重塑。

Vascular remodeling is the bottleneck of the prognosis and treatment of ischemic disease. A series of vascular biochemical signals were activated by hemodynarnic changes induced by machinery transduction mechanism. The vasoactive substances and cytokines secreted by endothelial cells, and growth factors secreted by smooth muscle cells, activate multiple signal transduction pathways, resulting in a set of changes such as vascular proliferation, apoptosis, migration, inflammation, and the secretion, deposition and degradation of extracellular matrix by the regulation of gene expression. In this paper, we elucidate the action of the cytokines and cell cycle regulatory proteins, and cell phenotype conversion, the inflammatory responses and the cell proliferation in vascular remodeling.