埃博拉病毒受体的研究进展

Research Progress of the Ebola Virus Receptors

埃博拉病毒能在人类和非人灵长类中引起严重的出血热疾病。1976年,国际上首次报道了埃博拉出血热病例,到2014年,非洲又爆发了历史上最严重的埃博拉疫情,然而,至今仍然没有明确的预防疫苗和治疗药物。与大多数病毒一样,埃博拉病毒需要入侵宿主细胞才能完成自身的复制。因此,找到埃博拉病毒入侵的受体并探究其入侵的过程和机制,对于开发病毒疫苗及新型治疗药物具有非常关键的作用。作者希望通过总结埃博拉病毒受体的研究进展,为埃博拉病毒疫苗及治疗药物的开发提供思路。

Ebola virus can cause severe Ebola hemorrhagic fever in human and non-human primates, including the most serious outbreak in 2014. Though it has been first described in Zaire in 1976, there are no definite prophylactic or therapeutic treatments available yet. Like most viruses, Ebola virus needs to invade host cells in order to complete their own copy. Therefore, finding out the Ebola virus receptors and exploring the process and mechanism, will play a key role in the development of virus vaccine and new drugs. This review summarized the research progress of Ebola virus receptors.