摘要
目的与非三阴性乳腺癌(non-TNBC)比较,探讨三阴性乳腺癌(TNBC)的乳腺X线特征。方法根据ER、PR、HER2表达情况,将737个乳腺癌肿块分成TNBC组(n=112)和non-TNBC组(n=625),回顾性分析两组患者的X线图像及临床病理资料。结果 TNBC肿瘤组织学分级高,腋窝淋巴结转移率高于non-TNBC组(P<0.05)。在钼靶X线中,TNBC主要表现肿块(69.7%),很少表现为肿块伴钙化(16.5%)、局限性非对称致密(4.6%)、单纯钙化(2.8%)和结构扭曲(6.4%);肿块形状多为圆形(30.9%)或椭圆形(38.3%),很少表现为不规则形(11.7%);肿块边缘多为清晰边缘(30.9%),毛刺肿块少见(19.1%)。non-TNBC通常表现为肿块伴钙化(43.5%),钙化多见(58.8%);肿块形态主要为分叶形(40.4%)和不规则形(28.9%),毛刺征多见(43.6%)。结论 TNBC有其独特的影像表现,更倾向于良性肿瘤的特点,了解其X线特征有助于提高TNBC的诊断水平。
Objective To investigate the mammographic features of triple-negative breast cancer (TNBC) in comparison to non-triple-negative breast cancer (non-TNBC). Methods According to the expression of ER, PR, and HER2, 737 breast cancers were divided into TNBC group (n= 112) and non-TNBC group (n= 625). And then we retrospectively ana- lyzed mammographic and clinicopathologic findings of the two groups. Results TNBC was associated with higher tumor grades and more axillary lymph node involvement ( P 〈0.05). On mammography, TNBCs frequently presented with mas- ses (69.7 %) and were less associated with masses with calcifications (16.5 %), focal asymmetric density (4.6 % ) , calcifi- cations alone (2. 8%) and architectural distortion (6. 4%). Masses were most frequently round (30. 9%) or oval (38.3%) in shape and were less frequently irregular in shape (11.7%). Masses with circumscribed margins were the most frequent (30.9 %), but spiculated margins were rare (19.1%). In contrast, in the non-TNBC group, masses with calcifi- cations were the most frequent (43. 5%) and calcifications were commonly observed (58. 8%). Masses were most fre- quently lobular (40. 4%) or irregular (28. 9%) in shape, and masses with spiculated margins were the most frequent (43.6%). Conclusion TNBC could have distinct mammographic features and is likely to manifest with benign imaging features. The mammographic findings might be useful for the diagnosis of TNBC.
出处
《医学影像学杂志》
2015年第7期1186-1190,共5页
Journal of Medical Imaging