全身^(18)F-FDGPET-CT显像在甲状腺疾病检测的价值

The Value of PET-CT ^(18)F-FDG Imaging in Thyroid Disease Detection

目的分析全身18F-FDG PET/CT对甲状腺疾病检测的临床诊断价值。方法选取本院2014年2月至2015年4月收治的600例肿瘤患者和健康受试者作为研究对象,采用PET/CT对患者进行全身扫描,通过EBW工作站对扫描数据进行处理得到三个不同轴位的断层图像和融合图像。采用PET/CT影像学方法测定甲状腺疾病的良、恶性判断,并研究标准摄取值(Standardized Uptake Value,SUV)用于诊断甲状腺良、恶性病变的临床价值。甲状腺疾病最终均需采用99m Tc-甲状腺扫描、甲状腺功能5项检查、穿刺或手术及6个月的跟踪随访而进行综合考虑才可确定。结果采用PET/CT影像学方法共查出甲状腺疾病患者52例,检出率为8.7%(52/600),其中第1-5种情况分别查出28例、2例、14例、4例和4例。其中良性病变的SUV值为(2.7±2.1),而恶性病变为(3.1±1.4),但经统计分析,不具有显著性差异(P>0.05)。结论采用全身18F-FDG PET/CT检查方法对甲状腺疾病的诊断具有一定的临床价值,仅采用SUV值对良、恶性病变的诊断效果不佳,需将CT和PET进行结合对良、恶性病变的诊断结果更加可靠。

Objective To analyze the clinical diagnostic value of PET/CT 18F-FDG for thyroid disease detection. Methods Selected in our hospital in 2014 February to April 2015 from 600 cases of tumor patients and healthy subjects as the object of study by PET/CT for patients with whole body scan, by EBW workstation on the scanning data were from three different axial tomographic images and fusion images. By PET/CT imaging method for determination of benign or malignant judgment of thyroid disease, and to study the standard uptake value（standardized uptake value, SUV） for the clinical value of diagnosis of thyroid benign and malignant lesions. Thyroid diseases ultimately need to use 99 m Tcthyroid scanning, thyroid function 5 examination, puncture or surgery and 6 months of follow-up and comprehensive consideration can be determined. Results Results 52 patients with thyroid disease were detected by PET/CT imaging, the detection rate was 8.7%（52/600）, and the cases of 1~5 were found in 28 cases, 2 cases, 14 cases, 4 cases and 4 cases.. The 1~4 diagnosis of PET/CT was more benign and the fifth cases were malignant.. The benign lesions of the SUV values（＋ 2.7 2.1）, and malignant lesions（＋ 3.1 1.4）, visible lesions from malignant than benign lesions, but the statistics analysis, has no significant difference（P〉0.05）. Conclusion Conclusion By whole body 18F-FDG PET/CT method for thyroid disease diagnosis has certain clinical value, only the SUV values poor effect in the diagnosis of benign and malignant lesions, should be combined with the diagnosis of benign and malignant lesions result more reliable CT and pet, when CT results show thyroid local density decreases, and elevated metabolic pet and SUV value higher than 2.5 for malignant lesions and diagnosis with high clinical value.