阿托伐他汀对高血压合并糖尿病患者颈动脉内膜中层厚度及相关生化指标的影响

The impact of atorvastatin on carotid artery intima-media thickness and biochemical indexes of patients with hypertension combined diabetes

目的比较40 mg/d与20 mg/d阿托伐他汀对高血压合并糖尿病患者颈动脉内膜中层厚度及生化指标的影响。方法观察组和对照组各48例,观察组在常规治疗的基础上给予40 mg/d阿托伐他汀强化降脂治疗;对照组在常规治疗的基础上给予20 mg/d阿托伐他汀治疗。比较两组CIMT、内皮依赖性血管舒张功能(FMD)、基质金属蛋白酶-9(MMP-9)、N末端脑钠肽原(NT-pro BNP)等指标。结果观察组CIMT、MMP-9、NT-pro BNP明显低于对照组,FMD明显高于对照组。结论阿托伐他汀强化降脂治疗有助于改善患者血脂水平与血管内皮功能,减少颈动脉内膜中层厚度,降低基质金属蛋白酶-9、N末端脑钠肽原表达,预防发生脑血管疾病风险。

【Objective】To study effect of 40 mg/d with 20 mg/d atorvastatin on carotid artery intima-media thickness and biochemical indexes of patients with hypertension combined diabetes. 【Methods】96 cases patients with hypertensive combined diabetes were divided into observation group and control group, observation group given 40 mg/d atorvastatin intensive treatment; control group given 20 mg/d atorvastatin treatment. CIMT, blood lipid, FMD, MMP-9, NT-pro BNP were compared between two groups. 【Results】Observation group TC, LDL-C were significantly lower than that control group CIMT, MMP-9, NT-pro BNP were significantly lower than that control group, FMD were significantly higher than that control group. 【Conclusion】Atorvastatin intensive treatment helps to improve blood lipid level and vascular endothelial function, reduce the carotid artery intima-media thickness, reduce MMP-9, NT-pro BNP expression, prevention of cerebrovascular disease risk.